Distribution of virulence genes and antimicrobial resistance of isolated from hospitalized neonates: A multi-center study across China.

Background: is the most common gram-negative pathogen to cause neonatal infections. Contemporary virulence characterization and antimicrobial resistance (AMR) data of neonatal isolates in China are limited.

Methods: A total of 159  strains isolated from neonates were collected and classified into invasive and non-invasive infection groups, according to their site of origin.

Janus Interface Engineering Boosting Visibly Transparent Radiative Cooling for Energy Saving.

Visibly transparent radiative cooling (VTRC) shows great potential in energy-saving buildings or car glasses for lighting and cooling. How to balance the lighting and cooling performance is of significance to VTRC. In addition, the thermal radiative performance on the inner side should also be determined for cooling.

Drug resistance characteristics and molecular typing of Escherichia coli isolates from neonates in class A tertiary hospitals: A multicentre study across China.

Objectives: Escherichia coli is a common pathogen causing invasive bacterial infections in neonates. In recent years, clinical antimicrobial susceptibility testing has demonstrated an increased rate of drug-resistant E. coli infections.

Highly solar reflectance and infrared transparent porous coating for non-contact heat dissipations.

Passive daytime radiative cooling (PDRC) can dissipate heat to outer space with high solar reflectance and thermal emittance in the atmospheric transmission window. However, for the non-contact heat dissipation, besides the high , a high infrared transmittance is needed to directly emit thermal radiation through the IR-transparent coating to outer space. In this work, An IR-transparent porous PE (P-PE) coating with = 0.

Designing Mesoporous Photonic Structures for High-Performance Passive Daytime Radiative Cooling.

Passive daytime radiative cooling (PDRC) has drawn significant attention recently for electricity-free cooling. Porous polymers are attractive for PDRC since they have excellent performance and scalability. A fundamental question remaining is how PDRC performance depends on pore properties (e.

RACO-1 modulates Hippo signalling in oesophageal squamous cell carcinoma.

Oesophageal cancer is one of the most lethal malignancies worldwide, whereas the 5-year survival is less than 20%. Although the detailed carcinogenic mechanisms are not totally clear, recent genomic sequencing data showed dysregulation of Hippo signalling could be a critical factor for oesophageal squamous cell carcinoma (ESCC) progression. Therefore, understanding of the molecular mechanisms that control Hippo signalling activity is of great importance to improve ESCC diagnostics and therapeutics.

Regulation of Hippo/YAP signaling and Esophageal Squamous Carcinoma progression by an E3 ubiquitin ligase PARK2.

Esophageal squamous cell carcinoma (ESCC) is one of the most commonly diagnosed cancer types in China. Recent genomic sequencing analysis indicated the over-activation of Hippo/YAP signaling might play important roles for the carcinogenic process and progression for ESCC patients. However, little is known about the molecular mechanisms that controls Hippo signaling activity in ESCC.

SHARPIN Inhibits Esophageal Squamous Cell Carcinoma Progression by Modulating Hippo Signaling.

Esophageal cancer is one of the leading malignancies worldwide, while around sixty percent of newly diagnosed cases are in China. In recent years, genome-wide sequencing studies and cancer biology studies show that Hippo signaling functions a critical role in esophageal squamous cell carcinoma (ESCC) progression, which could be a promising therapeutic targets in ESCC treatment. However, the detailed mechanisms of Hippo signaling dys-regulation in ESCC remain not clear.

The SIS model with diffusion of virus in the environment.

In this paper, we propose an SIS-type reaction-diffusion equations, which contains both direct transmission and indirect transmission via free-living and spatially diffusive bacteria/virus in the contaminated environment, motivated by the dynamics of hospital infections. We establish the basic reproduction number ₀ which can act as threshold level to determine whether the disease persists or not. In particular, if ₀<1 ="" ="" ="" ="" ="" ="" ="" ="" ="".

RNF168 facilitates proliferation and invasion of esophageal carcinoma, possibly via stabilizing STAT1.

Oesophageal cancer ranks as one of the most common malignancy in China and worldwide. Although genome-wide association studies and molecular biology studies aim to elucidate the driver molecules in oesophageal cancer progression, the detailed mechanisms remain to be identified. Interestingly, RNF168 (RING finger protein 168) shows a high frequency of gene amplification in oesophageal cancer from TCGA database.

Mucosal and systemic immunization with a novel attenuated pneumococcal vaccine candidate confer serotype independent protection against Streptococcus pneumoniae in mice.

Despite the availability of effective vaccines, Streptococcus pneumoniae is still one of the major infectious diseases causing substantial morbidity and mortality in children under 5 years old. In this study, we demonstrate the protective efficacy of S. pneumoniae SPY1, a novel live attenuated vaccine strain against pneumococcal infection in murine models.

[Contributions of putative lipoate-protein ligase to the virulence of Streptococcus pneumoniae].

Objective: To investigate the effect of putative lipoate-protein ligase (LPL) on the virulence of Streptococcus pneumoniae.

Methods: lpl gene deficient strain was constructed by LFH-PCR and identified by PCR and sequencing. The cell adherence assay and mice challenge assay were used to observe the differences between wild strain and the mutant in the pathopoiesis of Streptococcus pneumoniae.

[ComE-deficient mutant affects in vivo-induced genes expression in Streptococcus pneumoniae].

Objective: To screen in vivo genes of Streptococcus pneumoniae controlled by comE gene.

Methods: The comE-deficient strain was constructed by using insertion inactivation and identified by PCR and sequencing. The BALB/c mouse was used as test animal and injected with D39 wild type and D39 comE-deficient strain via intraperitoneal injection.

[Effect of clpE gene deletion on virulence of Streptococcus pneumoniae].

Objective: To study the effect of clpE gene deletion on the virulence of Streptococcus pneumoniae.

Methods: The clpE-deficient strain was constructed by LFH-PCR and identified by PCR and sequencing. The impact of clpE mutant on the virulence of S.