Smart contracts and homomorphic encryption for private P2P energy trading and demand response on blockchain.

Blockchain technology offers great value in terms of decentralization, data integrity, transparency, and traceability, however the transactional data is public, and accessible raising concerns about violating privacy regulations. For example, in the peer-to-peer energy trading and demand response use cases, the data stored in blockchain may allow a third party to infer the load profiles or even identify the behind the meter assets. In this paper, we employ homomorphic techniques to encrypt the energy transactional data stored on the blockchain allowing the smart contracts functions responsible for implementing the business logic of the energy flexibility trading and settlement to perform computations on encrypted data.

Privacy-Preserving Computation for Peer-to-Peer Energy Trading on a Public Blockchain.

To ensure the success of energy transition and achieve the target of reducing the carbon footprint of energy systems, the management of energy systems needs to be decentralized. Public blockchains offer favorable features to support energy sector democratization and reinforce citizens' trust, such as tamper-proof energy data registration and sharing, decentralization, transparency, and support for peer-to-peer (P2P) energy trading. However, in blockchain-based P2P energy markets, transactional data are public and accessible, which raises privacy concerns related to prosumers' energy profiles while lacking scalability and featuring high transactional costs.

Therapies beyond Physiological Barriers and Drug Resistance: A Pilot Study and Review of the Literature Investigating If Intrathecal Trastuzumab and New Treatment Options Can Improve Oncologic Outcomes in Leptomeningeal Metastases from HER2-Positive Breast Cancer.

Leptomeningeal metastases (LM) are a rare but rapidly fatal complication defined by the spread of tumor cells within the leptomeninges and the subarachnoid space, found in approximately 10% of patients with HER2-positive breast cancers. This pilot study evaluated the efficacy of local treatment with intrathecal Trastuzumab (IT) added to systemic treatment. The oncologic outcome of 14 patients with HER2-positive LM is reported.

Upstaging and Downstaging in Gliomas-Clinical Implications for the Fifth Edition of the World Health Organization Classification of Tumors of the Central Nervous System.

In 2021, the 5th edition of the WHO Classification of Tumors of the Central Nervous System (WHO-CNS5) was published as the sixth volume of the international standard for brain and spinal cord tumor classification. The most remarkable practical change in the current classification involves grading gliomas according to molecular characterization. IDH mutant (10%) and IDH wild-type tumors (90%) are two different entities that possess unique biological features and various clinical outcomes regarding treatment response and overall survival.

Novel C19orf12 loss-of-function variant leading to neurodegeneration with brain iron accumulation.

Neurodegeneration with brain iron accumulation (NBIA) is a group of inherited disorders characterised by cerebral iron overload mainly in the basal ganglia. Mitochondrial membrane protein-associated neurodegeneration (MPAN) is a form of NBIA caused by pathogenic C19orf12 gene variants. We report on a Romanian patient with MPAN confirmed through exome sequencing, revealing a homozygous nonsense variant in the C19orf12 gene, NM_001031726.

Fetal Surveillance in Pregnancies with Myasthenia Gravis.

Myasthenia gravis (MG) is an autoimmune condition, that commonly impacts adult women of reproductive age. Myasthenia gravis in pregnancy is rare, but the incidence is higher in different geographical areas. Pregnancies in mothers with MG can have an unfortunate outcome.