Publications by authors named "Dan Margulies"
Background: The purpose of this study was to evaluate how β-adrenergic receptor inhibition after traumatic brain injury (TBI) alters changes in early cerebral glucose metabolism and motor performance, as well as cerebral cytokine and heat shock protein (HSP) expression.
Methods: Mouse cerebral glucose metabolism was measured by microPET fluorodeoxyglucose uptake and converted into standardized uptake values (SUV). Four groups of C57/Bl6 mice (wild type [WT]) were initially evaluated: sham or TBI, followed by tail vein injection of either saline or a nonselective β-adrenergic receptor inhibitor (propranolol, 4 mg/kg).
The aim of this study was to assess how increasing age affects mortality in trauma patients with Glasgow Coma Scale (GCS) 3. The Los Angeles County Trauma System Database was queried for all patients aged 20 to 99 years admitted with GCS 3. Mortality was 41.
View Article and Find Full Text PDFBackground: Recent evidence suggests a survival advantage in trauma patients who receive controlled or hypotensive resuscitation volumes. This study examines the threshold crystalloid volume that is an independent risk factor for mortality after trauma.
Methods: This study analyzed prospectively collected data from a Level I Trauma Center between January 2000 and December 2008.
Article Synopsis
- Two major train crash incidents in Los Angeles in 2005 and 2008 revealed that victims were initially underutilizing trauma centers, leading to changes in disaster response plans.
- Analysis of data from the two incidents showed significant improvement in the 2008 MCI, with 93% of severely injured patients transported to trauma centers compared to 56% in 2005.
- The findings indicate that the new trauma system performance program effectively enhanced patient distribution based on injury severity, demonstrating better overall outcomes in response to mass casualty incidents.