Publications by authors named "Dan M Gorman"
Article Synopsis
- PILRs (PILRalpha and PILRbeta) play crucial roles in the immune response during acute Staphylococcus aureus pneumonia, with PILRalpha being inhibitory and PILRbeta being activating.
- Mice lacking PILRbeta or with activated PILRalpha showed better bacterial clearance and survival rates, alongside reduced pro-inflammatory cytokines and increased protective cytokines compared to control mice.
- The study suggests that manipulating PILR signals, especially enhancing the inhibitory pathway, can improve outcomes in S. aureus pneumonia, indicating the significance of PILRs in managing inflammation and innate immune response.
