Objective: To investigate the predictive value of a Short Physical Performance Battery (SPPB) for postoperative major adverse cardiovascular events(MACEs) in elderly patients undergoing major abdominal surgery and to develop a nomogram risk prediction model.
Methods: A total of 427 elderly patients aged ≥ 65 years who underwent major abdominal surgery at our hospital between June 2023 and March 2024 were selected for the study, and 416 patients were ultimately included. The preoperative SPPB score was measured, and the patients were divided into two groups: a high SPPB group (≥ 10) and a low SPPB group (< 10).
Despite the excellent advantages of biomicrorobots, such as autonomous navigation and targeting actuation, effective penetration and retention to deep lesion sites for effective therapy remains a longstanding challenge. Here, we present dual-engine cell microrobots, which we refer to as PR-robots, created by conjugating photosynthetic bacteria (PSB) with red blood cells (RBCs). The robots penetrate the tumor interior in swarms through combined hypoxic traction and ultrasound actuation (UA).
View Article and Find Full Text PDFObjectives: Lung cancer patients undergoing chemotherapy are present in multiple Nutrition Impact Symptoms (NIS). There have been no studies utilizing symptom networks to identify core NIS in lung cancer patients undergoing chemotherapy, it is necessary to identify core symptoms for effective and precise symptom management. We aimed to construct a symptom network of NIS in lung cancer patients receiving chemotherapy, and explore the core Nutrition Impact Symptoms cluster.
View Article and Find Full Text PDFIn this issue of Molecular Cell, Sun et al. reveal that the long non-coding RNA (lncRNA) DNAJC3-AS1 plays a dual role in maintaining the rRNA processing function of fibrillarin (FBL) in cancer cells. It promotes FBL condensation while preventing abnormal aggregation, offering new therapeutic insights for cancer treatment by targeting lncRNAs involved in the regulation of FBL condensation.
View Article and Find Full Text PDFThis research explored various concentrations of sodium dodecyl sulfate (SDS) and citric acid (CA), both individually and in combination, to assess their effectiveness against Salmonella biofilms in hydroponic agriculture systems. Results demonstrated that a combined sanitizer of 0.1% SDS (1.
View Article and Find Full Text PDFEthnopharmacological Relevance: Chinese patent medicine (CPM) is formulated using Chinese herbal medicines as raw materials according to prescribed methods and preparation processes. It is one of the most commonly used complementary and alternative therapies for insomnia in China. Dozens of CPMs have been applied in clinical settings to treat primary insomnia, and ample evidence has proven the efficacy and safety of various CPMs.
View Article and Find Full Text PDFImportance: Patients who undergo total laryngectomy lose the voice function permanently. It is important to reconstruct the voice function of the patients after total laryngectomy.
Objective: To explore a novel method for voice rehabilitation by suturing infrahyoid myocutaneous flaps to the hypopharyngeal and esophageal serosas after total laryngectomy and investigate its clinical efficacy.
Objective: To evaluate the metabolic changes of patients with schizophrenia treated with olanzapine and analyze the correlation between the dosage of the drug, the blood concentration and the clinical response, so as to provide a reference for the clinical diagnosis and treatment.
Methods: PubMed, web of science, Cochrane Library, MEDLINE databases were used to search for studies on olanzapine treatment in patients with schizophrenia, to extract changes in body weight, BMI, waist circumference, cholesterol, PANSS (The Positive and Negative Syndrome Scale), SAPS (The Positive Syndrome Scale), SANS (The Negative Syndrome Scale), BPRS (Brief Psychiatric Rating Scale), CGI (Clinical Global Impressions Ratings), and so on for meta-analysis, and to analyze the correlation of medication dose, blood concentration, and clinical response.
Results: Twenty clinical trials (1839 participants, 1058 male and 781 female patients) were included in this meta-analysis.
Transl Cancer Res
November 2024
Background: Glioblastoma (GBM) is a frequent malignant tumor in neurosurgery characterized by a high degree of heterogeneity and genetic instability. DNA double-strand breaks generated by homologous recombination deficiency (HRD) are a well-known contributor to genomic instability, which can encourage tumor development. It is unknown, however, whether the molecular characteristics linked with HRD have a predictive role in GBM.
View Article and Find Full Text PDFObjective: Cognitive dysfunction is a prevalent and intricate manifestation of schizophrenia (SCZ) that may be associated with distinct clinical factors and the presence of antioxidants, which relationship is unclear. The study aimed to investigate cognitive function and its influencing factors in Chinese patients with SCZ.
Methods: A group of 133 patients with SCZ and 120 healthy controls (HCs) were recruited.
Objective: By comparing the differences in pre-competition state anxiety, inter-competition heart rate variability (HRV), and shooting performance of young athletes of different grades, and revealing the correlation between these variables, it provides a potential basis for improving athletes' shooting performance.
Methods: A total of 45 adolescent shooters were selected in Chongqing, China, and completed 40 effective shots at self-pace in real shooting scenes. The pre-competition state anxiety, inter-competition HRV, and shooting performance of the athletes were monitored and evaluated respectively.
J Clin Endocrinol Metab
December 2024
Context: CD34+ orbital fibroblasts (OFs) play a pathogenic role in thyroid eye disease (TED). Several micro (mi)RNAs have been shown to promote TED progression.
Objective: This study aims to explore the regulatory effect of miRNAs on CD34+ OFs, to find potential therapeutic target.
Pharmacogenomics (PGx) holds the promise of personalizing medical treatments based on individual genetic profiles, thereby enhancing drug efficacy and safety. However, the current landscape of PGx research is hindered by fragmented data sources, time-consuming manual data extraction processes, and the need for comprehensive and up-to-date information. This study aims to address these challenges by evaluating the ability of Large Language Models (LLMs), specifically Llama3.
View Article and Find Full Text PDFPeriodontitis, an inflammatory and infectious disease resulting from dental plaque, affects tooth-supporting tissues and interconnects with various systemic conditions. Advancing periodontal tissue regeneration stands as pivotal in periodontitis treatment. Presently, odontogenic stem cells garner substantial interest for dental pulp functional tissue regeneration.
View Article and Find Full Text PDFAcute myeloid leukemia (AML) currently lacks a definitive cure. Studies have highlighted the involvement of SYTL4 expression levels in neoplasms, yet its specific roles in AML remain unexplored in the literature. Utilizing the TCGA and XENA databases, this study investigated SYTL4 expression levels in AML and identified associations between SYTL4 overexpression and clinicopathological features, prognosis, and immune infiltration in AML patients through genomic analysis.
View Article and Find Full Text PDFNa-S and K-S batteries, with high-energy density, using naturally more abundant and affordable metals compared with rare resources like Li, Co, and Ni elements, have inspired intense research interest. However, the sulfur cathodes for Na/K storage are plagued by soluble polysulfide shuttling, larger volumetric deformation, and sluggish redox kinetics. Here, we report that a conductive organosulfur polymer microcage, fabricated facilely with the microbe and elemental sulfur as precursors, can effectively address these issues for stable high-capacity Na-S and K-S batteries.
View Article and Find Full Text PDFBackground: Although Boston Naming Test has been thoroughly validated at a global level, there is limited assessment of item-level properties using modern psychometric methods.
Objective: This study aimed to investigate the construct validity and item-level properties of the color-picture version of Boston Naming Test (CP-BNT) in a Chinese cohort with neurodegenerative diseases.
Methods: This retrospective study included 424 participants, consisting of 118 normal controls, 152 with Alzheimer's disease, 101 with primary progressive aphasia, and 53 with other neurodegenerative diseases.
J Chem Inf Model
December 2024
Three-dimensional (3D) molecular generation models employ deep neural networks to simultaneously generate both topological representation and molecular conformations. Due to their advantages in utilizing the structural and interaction information on targets, as well as their reduced reliance on existing bioactivity data, these models have attracted widespread attention. However, limited training and testing data sets and the unexpected biases inherent in single evaluation metrics pose a significant challenge in comparing these models in practical settings.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
December 2024
Fluoride (F) are common in the environment and are beneficial in moderate amounts but can be harmful at high concentrations, leading to conditions such as fluorosis influenced by reactive oxygen species (ROS), including hypochlorite (ClO). This study introduces PZ-DT, a novel fluorescent probe with a phenothiazine core, designed for the sequential detection of F and ClO. PZ-DT emits orange-red fluorescence with a Stokes shift greater than 200 nm upon F detection, demonstrating excellent selectivity and sensitivity, boasting a quantum yield of 19.
View Article and Find Full Text PDFMicroRNAs (miRNAs) regulate gene expression post-transcriptionally, primarily through binding sites in 3' untranslated regions (3' UTRs). While computational and biochemical approaches have been developed to predict miRNA binding sites on target messenger RNAs, reliable and high-throughput assessment of the regulatory effects of miRNAs on full-length 3' UTRs can still be challenging. Utilizing a miniaturized and high-throughput reporter assay, we present a 'pilot miRNA-targeting map', containing 4,994 successfully measured miRNA:3' UTR regulatory outputs by pairwise assays between 461 miRNAs and eleven 3' UTRs.
View Article and Find Full Text PDFDiabetic ulcers are chronic wounds that are notoriously difficult to treat, leading to significant physical and psychological distress and increased healthcare costs. Their multifactorial aetiology necessitates long-term interdisciplinary collaboration and various complementary treatment measures. While numerous studies suggest that electrical stimulation (ES) positively impacts diabetic ulcer healing, the robustness and consistency of these findings require further evaluation to optimize clinical application.
View Article and Find Full Text PDFAstaxanthin, a lipid-soluble carotenoid, is widely recognized for its health-promoting properties. However, its use in functional foods is limited due to its low water solubility, chemical instability, and poor bioavailability. This study evaluated the potential of esterified starch-stabilized emulsions as astaxanthin carriers.
View Article and Find Full Text PDFCholangiocarcinoma (CCA) is a highly lethal malignancy with rising incidence, high mortality, poor overall survival rates, and limited responsiveness to traditional chemo-radiotherapy. Targeted therapies addressing specific gene mutations have expanded treatment options for some patient populations. The introduction of chimeric antigen receptor-modified T cell (CAR-T) immunotherapy and personalized vaccines have opened up a new avenue for managing various cancers.
View Article and Find Full Text PDFVitiligo is an autoimmune skin disease that targets pigment-producing melanocytes and results in depigmentation. This disfiguring condition frequently affects visible areas of the body and therefore causes a heavy psychological burden and a decreased quality of life. Although remains intractable, the evergrowing understanding of its immunopathogenesis has dramatically shaped the treatment paradigm for vitiligo.
View Article and Find Full Text PDFBackground: This study aimed to evaluate the predictive value of baseline PD-L1 targeted peptide Ga-NOTA-WL12 PET/CT in neoadjuvant immunotherapy combined with chemotherapy of resectable NSCLC.
Methods: Patients with resectable NSCLC (n = 20) enrolled in this prospective study received baseline paired Ga-NOTA-WL12 PET/CT and F-FDG PET/CT. After 2-4 cycles of toripalimab plus nab-paclitaxel and cisplatin, surgery was performed if R0 resection was available.