Publications by authors named "Dan Kechele"
In this case report, we describe the clinical course of a neonate who presented initially with respiratory distress and later with choking during feeding. He was subsequently found to have an esophageal bronchus to the right upper lung lobe, a rare communicating bronchopulmonary foregut malformation. Histological and molecular analysis of the fistula and distal tissues revealed that the proximal epithelium from the esophageal bronchus has characteristics of both esophageal and respiratory epithelia.
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- RAP GTPases are key regulators in platelet function, with a focus on the isoform RAP1B, which is found to be partially involved in platelet activation but not crucial for platelet count.
- Mice with a specific deletion of RAP isoforms displayed significant abnormalities in platelet production and functions, such as impaired aggregation and clot retraction.
- The study highlights that while RAP signaling is vital for platelet integrin activation and production, it is not necessary for maintaining vascular integrity during development or inflammation.