Metformin monotherapy in youth with recent onset type 2 diabetes: experience from the prerandomization run-in phase of the TODAY study.

Background: TODAY (Treatment Options for type 2 Diabetes in Adolescents and Youth) is a federally funded multicenter randomized clinical trial comparing three treatments of youth onset type 2 diabetes.

Objective: To describe the experience of youth participating in a 2-6 month run-in period in preparation for randomization into TODAY.

Subjects: An ethnically diverse sample of 927 youth, 65.