Impact of fixed phosphorus position on activity of triazole bisphosphonates as geranylgeranyl diphosphate synthase inhibitors.

Geranylgeranyl diphosphate synthase (GGDPS) produces the 20-carbon isoprenoid species used in protein geranylgeranylation reactions. Inhibition of GGDPS has emerged as a novel means of disrupting the activity of geranylgeranylated proteins in cancers such as myeloma and osteosarcoma. We have focused on developing a series of isoprenoid triazole bisphosphonate-based GGDPS inhibitors, demonstrating a complex structure-activity relationship (SAR), not only at the enzymatic level, but also at the cellular and whole organism levels.

Pregnancy outcomes following different surgical approaches for heterotopic interstitial and angular pregnancy.

Objective: To investigate the perioperative and pregnancy outcomes among different surgical approaches and methods for treating heterotopic pregnancy (HP) and to identify the risk factors for the loss of intrauterine pregnancy (IUP).

Methods: We retrospectively reviewed 59 cases of interstitial and angular HP treated surgically between 2014 and 2024 in two women's health centers in southwest China. Surgical methods included multi-port laparoscopy (MPL), transumbilical laparoendoscopic single-site surgery (TU-LESS), and conventional laparotomy (CL), along with cornual wedge resection and linear incision.

The effects of a 12-week moderate-intensity continuous training intervention on depression, anxiety, and stress in sedentary female college students: a focus on negative emotion regulation.

Objective: Moderate Intensity Continuous Training (MICT) is recognized as an effective intervention for improving negative affect. However, research on its effects across varying levels of negative mood states in sedentary female college students remains limited. This study aimed to investigate the impact of a 12-week MICT intervention on different levels of negative mood in sedentary female college students.

Cross-Domain Communication Method Based on Load Balancing for SDNs.

In multi-end-to-end path request planning, the control plane may not be able to meet all path request requirements under limited bandwidth resources. Moreover, suboptimal path planning can lead to localized network congestion, which in turn causes an overall imbalance in network load. Therefore, the multi-domain control plane needs to consider more network resource states during the path selection, such as link weights, load saturation, and resource occupancy rates, in order to select the optimal paths to maximize the satisfaction of data plane requirements while maintaining network load balance.

Effects of Heat Treatment on Physicochemical Properties of Lam. Leaf Protein.

leaves represent a novel and nutritious food. Prior research has demonstrated that leaves can elicit allergic responses in BALB/c mice. Based on these findings, further studies were conducted to investigate the effects of heat treatment on the allergenicity, particle size, zeta potential, total sulfhydryl (TSH) content, hydrophilicity and hydrophobicity, ultraviolet spectrum, and intrinsic fluorescence spectrum of leaf protein.

Opposing Functions of Distinct Regulatory T Cell Subsets in Colorectal Cancer.

Regulatory T (Treg) cells contribute to solid organ cancer progression, except in colorectal cancer (CRC) despite being abundantly present. Here, we demonstrate that two distinct tumoral IL-10⁺ and IL-10⁻ Treg cell subsets exert opposing functions by counteracting and promoting CRC tumor growth, respectively. The tumor restraining activity of IL-10⁺ Treg cells was mediated by their suppression of effector CD4 T cell production of IL-17, which directly stimulates CRC tumor cell proliferation.

Analysis of the sensitization activity of leaves protein.

The determination of allergenic proteins in leaves, which is the main components of immune activity, has enabled the development of a more effective method for evaluating the activity of extracted leaves protein. In this study, the extraction process of leaves protein was optimized based on a single factor experiment. The hemagglutination-related properties of leaves protein, such as (thermal, acid-base) stability, sugar binding specificity, ion binding characteristics, and hemolytic activity, were detected.

Glucocorticoids on bone remodeling in systemic lupus erythematosus mice.

Background: Systemic lupus erythematosus requires glucocorticoids for management. This study investigates how glucocorticoids influence bone in a SLE mouse model, focusing on bone mineral density (BMD), microstructure, and remodeling markers.

Methods: MRL/lpr and C57BL/6 mice were administered dexamethasone or saline as a control for 4-weeks.

Effectiveness of nursing signs in reducing risk events in the management of elderly patients with fracture.

Objective: To investigate the application value of nursing signs in the risk management of elderly fracture patients.

Methods: A total of 88 elderly fracture patients admitted to West China Hospital between April 2021 and August 2022, along with 12 nursing staff members, were selected as study participants. The clinical data of these patients were retrospectively analyzed, and the patients were divided into two groups based on the nursing management strategy employed.

Insights into the mechanisms, regulation, and therapeutic implications of extracellular matrix stiffness in cancer.

The tumor microenvironment (TME) is critical for cancer initiation, growth, metastasis, and therapeutic resistance. The extracellular matrix (ECM) is a significant tumor component that serves various functions, including mechanical support, TME regulation, and signal molecule generation. The quantity and cross-linking status of ECM components are crucial factors in tumor development, as they determine tissue stiffness and the interaction between stiff TME and cancer cells, resulting in aberrant mechanotransduction, proliferation, migration, invasion, angiogenesis, immune evasion, and treatment resistance.

Latent profiles and determinants of postoperative sleep quality in elective surgery patients.

It is crucial to determine the potential subgroups of sleep disturbances in patients undergoing elective surgery based on the importance of symptom clusters and individual characteristics in order to develop targeted symptom management plans. This study explored the potential categories of postoperative sleep disturbances in patients undergoing elective surgery through latent profile analysis, and explored the influencing factors of each category. A total of 400 eligible elective surgery patients were included in the analysis, and three potential subgroups were identified: mild sleep disturbance group (c1 = 140,35.

Single-cell transcriptomes reveal spatiotemporal heat stress response in maize roots.

Plant roots perceive heat stress (HS) and adapt their architecture accordingly, which in turn influence the yield in crops. Investigating their heterogeneity and cell type-specific response to HS is essential for improving crop resilience. Here, we generate single-cell transcriptional landscape of maize (Zea mays) roots in response to HS.

Risk classification assessment and early warning of large deformation of soft rock in tunnels based on CNN-LSTM model.

Tunnels in the Western Plateau region of China often face numerous problems of high ground stress, as well as highly fractured and weak rock masses in deep sections of the tunnel, which results in an increased risk of large soft rock deformation in tunnels, posing substantial challenges to safe and efficient construction. Hence, risk assessment and establishment of an early safety warning system are essential. By examining factors affecting the large soft rock deformation in tunnels, a set of index system consisting of three primary indicators (i.

LncRNA MALAT1 Facilitates Parkinson's Disease Progression by Increasing SOCS3 Promoter Methylation.

Introduction: Long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been shown to be involved in Parkinson's disease (PD) progression, but its mechanism needs to be further explored.

Methods: Mice were injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to induce PD mice models, and BV2 cells were treated with lipopolysaccharides (LPS) to mimic PD cell models. MALAT1 expression and suppressor of cytokine signaling 3 (SOCS3) protein level were examined using quantitative real-time PCR and Western blot, respectively.

IFIT3 mediates TBK1 phosphorylation to promote activation of pDCs and exacerbate systemic sclerosis in mice.

Objective: To assess the impact of the IFIT3/TBK1 signalling pathway in activating plasmacytoid dendritic cells (pDCs) and its role in the development of SSc.

Methods: Utilized single-cell RNA sequencing (scRNA-seq) and high-throughput transcriptome RNA sequencing to reveal the differential abundance of pDCs and the role of the key gene IFIT3 in SSc. Conducted in vitro cell experiments to evaluate the effect of IFIT3/TBK1 signalling pathway intervention on pDC activation cytokine release and fibroblast function.

Study on the phase transformation mechanism and influencing factors of inorganic condensable particulate matter from coal-fired power plants.

In this study, the concentration of inorganic ions (SO, NH, NO and NO) and morphological characteristics of condensable particulate matter (CPM) were investigated to elucidate the formation mechanism of inorganic CPM from ultra-low emission coal-fired power plants. The concentration of inorganic ions increased with the increase of HO content and concentration of inorganic gaseous contaminants (SO, NO and NH), and decrease of condensation temperature, indicating the enhancement of heterogenous reaction in the saturated flue gas. Furthermore, NO and SO could undergo redox reactions, leading to an elevation in the concentration of SO and NO.