Discovery of novel arylamide derivatives containing piperazine moiety as inhibitors of tubulin polymerisation with potent liver cancer inhibitory activity.

In this work, a series of novel arylamide derivatives containing piperazine moiety were designed and synthesised as tubulin polymerisation inhibitors. Among 25 target compounds, compound () exhibited low nanomolar IC values ranging from 0.089 to 0.

E3 ubiquitin ligase ring finger protein 5 protects against hepatic ischemia reperfusion injury by mediating phosphoglycerate mutase family member 5 ubiquitination.

Background And Aims: Hepatic ischemia-reperfusion (HIR) injury, a common clinical complication of liver transplantation and resection, affects patient prognosis. Ring finger protein 5 (RNF5) is an E3 ubiquitin ligase that plays important roles in endoplasmic reticulum stress, unfolded protein reactions, and inflammatory responses; however, its role in HIR is unclear.

Approach And Results: RNF5 expression was significantly down-regulated during HIR in mice and hepatocytes.

Regulator of G-protein signaling 14 protects the liver from ischemia-reperfusion injury by suppressing TGF-β-activated kinase 1 activation.

Background And Aims: Hepatic ischemia-reperfusion injury (IRI) is a common complication of hepatectomy and liver transplantation. However, the mechanisms underlying hepatic IRI have not been fully elucidated. Regulator of G-protein signaling 14 (RGS14) is a multifunctional scaffolding protein that integrates the G-protein and mitogen-activated protein kinase (MAPK) signaling pathways.

Synaptopodin-2 promotes hepatocellular carcinoma metastasis via calcineurin-induced nuclear-cytoplasmic translocation.

Hepatocellular carcinoma (HCC), a type of malignant liver tumor, has a grim prognosis. As a functional protein, synaptopodin-2 (SYNPO2) has been associated with malignancy; however, the expression profile and function of SYNPO2 in HCC remains unknown. Herein, we revealed that SYNPO2 was transcriptionally downregulated in HCC tissues from both The Cancer Genome Atlas cohort and our cohort, and was also decreased at the translational level as determined by western blotting and immunohistochemical staining.

Quantitative analysis of segmented planar imaging quality based on hierarchical multistage sampling lens array.

Segmented Planar Imaging is an advanced technology for ultra-thin, high-resolution imaging with photonic integrated circuit (PIC). In this paper, a segmented planar imager with a novel hierarchical multistage sampling lens array is proposed, which can effectively improve the sampling of low and medium frequency information. Based on the novel lens array architecture, a full-chain signal level model of the segmented planar imaging system is established, considering the fill factor of lens array and the wavelength spacing of the arrayed waveguide grating in PICs.

[Role of lymphatics in bacterial translocation from intestine in burn rats].

Objective: To investigate the role of lymphatics in bacterial translocation from intestine of rats with burn.

Methods: Escherichia coli (E. coli) labeled with chloromethylbenzamidodialkylcarbocyanine (CM-DIL) were prepared.

[A basic study and clinical trial of 585 nm pulsed dye laser in the treatment of congestive scars].

Objective: To study the biological effects of 585 nm pulsed dye laser (FLPDL) in the treatment of congestive scar.

Methods: By histological study, collagen VG staining and microvascular staining, we investigated the changes of collagen fibers and the density of microvessels in the congestive scars after FLPDL treatment.

Results: Histological and immunohistochemistry examinations showed that FLPDL achieved normal vascularity in the scar after over 3 times of treatment.