PBVD regimen (pegylated liposomal doxorubicin, bleomycin, vincristine, dacarbazine) in classical Hodgkin lymphoma patients with cardiovascular risk factors: a retrospective study.

This retrospective study aimed to evaluate the efficacy and safety of PBVD (pegylated liposomal doxorubicin [PLD], bleomycin, vinblastine, and dacarbazine) in the first-line treatment of classical Hodgkin lymphoma (cHL) patients with cardiovascular risk factors. Overall, 84 patients (53 had stage I-II and 31 had stage III-IV disease) received PBVD. The median PLD treatment duration was 16 weeks (interquartile range [IQR]: 8-24) for stage I-II and 24 weeks (IQR: 12-24) for stage III-IV.

Mechanism Insights into the Enantioselective Bioactivity and Fumonisin Biosynthesis of Mefentrifluconazole to .

The occurrence of maize ear rot caused by () poses a threat to the yield and quality of maize. Mefentrifluconazole enantiomers appear to have strong stereoselective activity against and cause differences in fumonisin production. We evaluated the stereoselective activity of mefentrifluconazole enantiomers by determining inhibition of the strain, hyphae, and conidia.

Effects of wheat varieties, fungicides and application time on Fusarium head blight and deoxynivalenol contamination control in wheat.

Background: Yield loss and toxin contamination caused by wheat Fusarium head blight (FHB) have always been a worldwide concern. Cultivating disease-resistant varieties and fungicide application are effective measures to control FHB. The comprehensive control technology system for FHB and toxin contamination of wheat in Anhui Province needs further improvement.

Ecological threat caused by malathion and its chiral metabolite in a honey bee-rape system: Stereoselective exposure risk and the mechanism revealed by proteome.

Honey bees play an important role in the ecological environment. Regrettably, a decline in honey bee colonies caused by chemical insecticides has occurred throughout the world. Potential stereoselective toxicity of chiral insecticides may be a hidden source of danger to bee colonies.

Enantioselective Degradation and Bioactivity Mechanism of a New Chiral Fungicide Fluindapyr in Paddy Ecosystems.

Fluindapyr is a novel chiral succinate dehydrogenase inhibitor used to control fungal diseases. The enantioselective effects of fluindapyr in paddy ecosystems are unknown. We developed a new chiral determination method of fluindapyr using ultrahigh performance liquid chromatography tandem mass spectrometry.

Antibacterial and antioxidant metabolites from the insect-associated fungus Aspergillus fumigatus.

The research on bioactive secondary metabolites from Aspergillus fumigatus afforded six compounds, which were identified by mass spectrometer (MS) and nuclear magnetic resonance (NMR) spectroscopic analysis as cyclopyazonic acid (1), trypacidin A (2), asterric acid (3), methyl asterrate (4), demethylcitreoviranol (5), as well as (5-hydroxy-2-oxo-2H-pyran-4-yl) methyl acetate (6). Cyclopyazonic acid (1) was found to have potent antibacterial effects, especially against Bacillus licheniformis with minimal inhibitory concentration (MIC) value of 3.7μg/mL.

Graphene-based materials: A new tool to fight against breast cancer.

Breast cancer is one of the most common malignant tumors among women population on a global scale, with a huge number of new cases and deaths each year. In recent years, there has been an increasing number of literatures on the discovery and development of novel anti-breast cancer drugs and materials, aiming to increase the survival rate of breast cancer patients. One of the newest tools used for the therapy of breast cancer is graphene-based materials, which have ultra-high surface area as well as unique physical, chemical and mechanical properties.

Antioxidant epoxydon and benzolactone derivatives from the insect-associated fungus sp.

One new epoxydon ester () and a new benzolactone derivative (), along with four known compounds (-), were isolated from the insect-associated fungus sp. Their structures were confirmed by extensive MS and NMR spectroscopic analysis and their absolute configurations were determined by a combination of modified Mosher method and Mo(OCOCH)-induced electronic circular dichroism (ECD) experiments. Compounds and were revealed to have potent antioxidant activities, which were approximate to the potency of the positive control trolox.

Combined Treatment with Autologous CIK Cells, Radiotherapy and Chemotherapy in Advanced Cervical Cancer.

To investigate the clinical efficacy of autologous cytokine induced killer (CIK) cells transfusion combined with radiochemotherapy in the treatment of advanced cervical cancer. A total of 89 hospitalized patients with advanced cervical cancer were admitted and divided into the treatment group (44 cases, autologous CIK cells transfusion combined with radiochemotherapy) and the control group (45 cases, radiochemotherapy) by a randomized non-blind method. Comparisons of therapeutic efficacies, immune functions, life qualities and survival rates were analyzed between the two groups.

Antioxidant coumarin and pyrone derivatives from the insect-associated fungus .

Two new compounds, versicolones A and B ( and ), and three known pyrone derivatives (-) were isolated from the insect-associated fungus . Their structures were elucidated through a combination of HRESIMS and NMR spectroscopic analysis. Versicolone A () was revealed as a coumarin derivative with the rare 5-alkyl side chain substitution.

Overexpression of HOTAIR leads to radioresistance of human cervical cancer via promoting HIF-1α expression.

Background: HOTAIR was known to enhance radioresistance in several cancers. However, the function of HOTAIR on radioresistance involving the regulation of HIF-1α in cervical cancer has not been reported.

Methods: BALB/c nude mice were injected subcutaneously with HeLa cells and irradiated by X-ray.

Assembly of Zn(II) and Cd(II) coordination polymers based on a flexible multicarboxylate ligand and nitrogen-containing auxiliary ligands through a mixed-ligand synthetic strategy: syntheses, structures and fluorescence properties.

The structures of coordination polymers are strongly influenced by the organic ligands and metal ions used for their construction, so it is important to choose suitable ligands and metal ions and appropriate synthetic processes. Two novel d(10) coordination polymers, namely poly[[diaquabis(2,2'-bipyridine)[μ4-4,4'-(1,4-phenylenedioxy)bis(benzene-1,2-dicarboxylato)]dizinc(II)] dihydrate], {[Zn2(C22H10O10)(C10H8N2)2(H2O)2]·2H2O}n, (1), and poly[[diaquabis(1,10-phenanthroline)[μ4-4,4'-(1,4-phenylenedioxy)bis(benzene-1,2-dicarboxylato)]dicadmium(II)] dimethylformamide disolvate], {[Cd2(C22H10O10)(C12H8N2)2(H2O)2]·2C3H7NO}n, (2), have been synthesized from 4,4'-(1,4-phenylenedioxy)bis(benzene-1,2-dicarboxylic acid) (H4L) and two different N-containing auxiliary ligands through a mixed-ligand synthetic strategy under a solvothermal environment. The structures were characterized by single-crystal X-ray diffraction, powder X-ray diffraction, elemental analysis and IR spectroscopy.