Publications by authors named "Dan D Buchanan"
Article Synopsis
- A deep learning algorithm called QuantCRC analyzes tumor morphologic features in stage III colon cancer to improve patient risk assessment based on DNA mismatch repair (MMR) status.
- The study found significant differences in tumor features between deficient (d-MMR) and proficient (p-MMR) tumors, impacting prognosis and recurrence rates.
- Results suggest that QuantCRC can effectively identify prognostic markers in routine tumor sections, potentially advancing understanding of cancer pathology and patient outcomes.
Background: Substantial evidence supports an association between use of menopausal hormone therapy and decreased colorectal cancer (CRC) risk, indicating a role of exogenous sex hormones in CRC development. However, findings on endogenous oestrogen exposure and CRC are inconsistent.
Methods: We used a Mendelian randomisation approach to test for a causal effect of age at menarche and age at menopause as surrogates for endogenous oestrogen exposure on CRC risk.