Publications by authors named "Dan Crooks"
Article Synopsis
- Many cancers rely on aerobic glycolysis, prompting research into lactate dehydrogenase (LDH) inhibitors, but effective agents have been elusive.
- A new LDH inhibitor shows strong activity in live cancer models (MIA PaCa-2 and HT29), highlighting its potential as a viable drug target with observable anti-tumor effects.
- Advanced imaging techniques (HP-MRSI) reveal that LDH inhibition quickly reshapes tumor metabolism, leading to decreased tumor growth when both mitochondrial complex 1 and LDH are inhibited.
We report a novel mechanism of action of ONC201 as a mitochondria-targeting drug in cancer cells. ONC201 was originally identified as a small molecule that induces transcription of TNF-related apoptosis-inducing ligand (TRAIL) and subsequently kills cancer cells by activating TRAIL death receptors. In this study, we examined ONC201 toxicity on multiple human breast and endometrial cancer cell lines.
View Article and Find Full Text PDFChronic elevated exposure to manganese (Mn) is associated with neurocognitive and fine motor deficits in children. However, relatively little is understood about cellular responses to Mn spanning the transition between physiologic to toxic levels of exposure. Here, we investigated the specificity, sensitivity, and time course of the Golgi Phosphoprotein 4 (GPP130) response to Mn exposure in AF5 GABAergic neuronal cells, and we determined the extent to which GPP130 degradation occurs in brain cells in vivo in rats subchronically exposed to Mn.
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