Driving under the Influence of Flualprazolam: 11 Case Reports.

Eleven cases of suspected driving under the influence (DUI) of flualprazolam are presented. Data from police reports and drug recognition examinations (DRE), when available, were evaluated. In all cases, significant driving impairments were observed including weaving, driving slowly, stopping in the roadway, or collisions.

Unusually High Concentration of Fentanyl in a Driver: A Case Report.

A case of driving under the influence of drugs with an extremely high blood fentanyl concentration and concomitant use of methamphetamine is presented. As the increase of the appearance of fentanyl in drug seizures continues, the likelihood of tolerant users increases as well. Data presented on fentanyl in antemortem cases over time from several regions of North America show geographic differences on whether fentanyl concentrations are increasing.

Isoform-specific and signaling-dependent propagation of acute myeloid leukemia by Wilms tumor 1.

Acute myeloid leukemia (AML) is caused by recurrent mutations in members of the gene regulatory and signaling machinery that control hematopoietic progenitor cell growth and differentiation. Here, we show that the transcription factor WT1 forms a major node in the rewired mutation-specific gene regulatory networks of multiple AML subtypes. WT1 is frequently either mutated or upregulated in AML, and its expression is predictive for relapse.