Clinical Significance of Organic Anion Transporting Polypeptide Gene Expression in High-Grade Serous Ovarian Cancer.

High-grade serous ovarian cancer (HGSOC) is considered the most deadly and frequently occurring type of ovarian cancer and is associated with various molecular compositions and growth patterns. Evaluating the mRNA expression pattern of the organic anion transporters (OATPs) encoded by genes may allow for improved stratification of HGSOC patients for targeted invention. The expression of mRNA and genes coding for putative functionally related ABC-efflux pumps, enzymes, pregnane-X-receptor, and (coding for estrogen receptors ERα and ERß) and HER-2 were assessed using RT-qPCR.

Role of IGF-I in Primary Ovarian Cancer - A Study of the OVCAD European Consortium.

Background/aim: IGF-I (insulin growth factor 1) is crucially involved in cellular proliferation. Moreover, deregulation of IGF-I has been shown to be relevant in the carcinogenesis of various tumor entities. However, the impact of IGF-I in epithelial ovarian cancer (EOC) is unclear.