Antiproliferative activity of aqueous leaf extract of Annona muricata L. on the prostate, BPH-1 cells, and some target genes.

Background: Annona muricata L. has been reported to possess antitumor and antiproliferative properties. Not much work has been done on its effect on BPH-1 cell lines, and no in vivo studies targeting the prostate organ exist.

Anti-atherogenic and anti-ischemic potentials of Croton membranaceus observed during sub-chronic toxicity studies.

Background: Croton membranaceus (CM) is used for benign prostate hyperplasia treatment.

Objective: Sub-chronic toxicity studies are non-existent and provided the basis for this study.

Materials And Methods: 90 days oral administration of a low dose (LD) (30 mg/kg b.