Publications by authors named "Dammy Pinheiro"
The Forkhead box transcription factor FoxP3 is pivotal to the development and function of regulatory T cells (Tregs), which make a major contribution to peripheral tolerance. FoxP3 is believed to perform a regulatory role in all the vertebrate species in which it has been detected. The prevailing view is that FoxP3 is absent in birds and that avian Tregs rely on alternative developmental and suppressive pathways.
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- The cancer microenvironment significantly influences the development of cancer by containing regulatory cells that weaken the body's immune response against tumors.
- In a study of dogs with multicentric B cell lymphoma, higher levels of FOXP3(+) T cells in lymph nodes were found to negatively affect both progression-free and overall survival rates.
- This suggests that Tregs may play a similar role in canine multicentric B cell lymphoma as in human diffuse large B cell lymphoma, making dogs a valuable model for studying immunoregulatory mechanisms in cancer.
Relatively little is known about regulatory T (Treg) cells and their functional responses in dogs. We have used the cross-reactive anti-mouse/rat Foxp3 antibody clone FJK-16s to identify a population of canine CD4(+) FOXP3(high) T cells in both the peripheral blood (PB) and popliteal lymph node (LN). FOXP3(+) cells in both PB and LN yielded positive staining with the newly developed anti-murine/human Helios antibody clone 22F6, consistent with the notion that they were naturally occurring Treg cells.
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