Plant formulation ATRICOV 452 in improving the level of COVID-19 specific inflammatory markers in patients.

Importance: Due to the huge demand for healthcare facilities, there is a need for safe therapeutic intervention which can reduce the need for extensive healthcare support.

Objective: In phase 1, to determine the safety of plant formulation in healthy volunteers and in phase 2, to validate its potential to improve the level of COVID-19 specific inflammatory markers.

Design: Setting, and Participants: The phase 1 single fasting dose study was conducted on 24 healthy adult human volunteers to evaluate the safety and tolerability of plant formulation.

In silico, screening of plant extracts for anti-SARS-CoV-2 activity and evaluation of their acute and sub-acute toxicity.

Background: In the absence of a specific drug for COVID 19, treatment with plant extracts could be an option worthy of further investigation and has motivated to evaluate the safety and anti-SARS-CoV-2 activity of plant extracts.

Purpose: To screen the phytochemicals for anti-SARS-CoV-2 and evaluate their safety and efficacy and

Method: The phytochemicals for anti-SARS-CoV-2 were screened using molecular docking. The hits generated from screening were subjected for extraction, isolation and purification.

screening of known small molecules to bind ACE2 specific RBD on Spike glycoprotein of SARS-CoV-2 for repurposing against COVID-19.

: Human coronavirus (SARS-CoV-2) is causing a pandemic with significant morbidity and mortality. As no effective novel drugs are available currently, drug repurposing is an alternative intervention strategy. Here we present an   drug repurposing study that implements successful concepts of computer-aided drug design (CADD) technology for repurposing known drugs to interfere with viral cellular entry via the spike glycoprotein (SARS-CoV-2-S), which mediates host cell entry via the hACE2 receptor.

Steroid sparing effect of a herbal preparation in steroid-dependent nephrotic syndrome.

Investigations on plants are revealing the potential therapeutic benefits of medicinal herbs in treating immunological disorders. Nephrotic syndrome has emerged as an immunological disorder. Steroid dependence poses a therapeutic challenge in the management of nephrotic syndrome.