Publications by authors named "Damien Viglino"

Because 20-30% of patients with sepsis deteriorate to critical illness, biomarkers that provide accurate early prognosis may identify which patients need more intensive treatment versus safe early discharge. The objective was to test the performance of sVEGFR2, suPAR and PCT, alone or combined with clinical signs and symptoms, for the prediction of clinical deterioration. This prospective observational study enrolled patients with suspected infection who met SIRS criteria without organ dysfunction (delta SOFA <2 from baseline) from 16 emergency departments.

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Article Synopsis
  • The study is trying to help families make tough choices about stopping life-support in emergency rooms when patients can't talk.
  • They will create a special program to help families, doctors, and nurses with these decisions and check how it affects the stress levels of the families.
  • The research will take place in nine emergency departments in France and will measure how families feel after 7, 30, and 90 days, making sure everything follows ethical rules.
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Objective: In many countries, the first line response to an emergency call is decided by the emergency dispatch center EMS clinician. Our main objective was to compare the pre-hospital response to calls received from cancer and non-cancer patients. We also compared the reasons for calling, for each group.

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Background: Prophylactic anticoagulation in emergency department patients with lower limb trauma requiring immobilisation is controversial. The Thrombosis Risk Prediction for Patients with Cast Immobilisation-TRiP(cast)-score could identify a large subgroup of patients at low risk of venous thromboembolism for whom prophylactic anticoagulation can be safely withheld. We aimed to prospectively assess the safety of withholding anticoagulation for patients with lower limb trauma at low risk of venous thromboembolism, defined by a TRiP(cast) score of less than 7.

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  • - Tracheal intubation is typically advised for coma patients, but its effectiveness in those with acute poisoning remains unclear; a study aimed to evaluate whether withholding intubation would affect outcomes for these patients.
  • - The multicenter randomized trial took place across 20 emergency departments and 1 ICU in France and involved 225 comatose patients with severe poisoning, comparing a conservative approach to standard intubation practices.
  • - Results indicated that patients in the conservative treatment group had better clinical outcomes, lower intubation rates, fewer adverse events, and a reduced incidence of pneumonia compared to those receiving routine intubation.
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Background: Exercise-induced O desaturation contributes to dyspnea and exercise intolerance in various respiratory diseases. This study assessed whether automated O titration was superior to fixed-flow O to improve exertional dyspnea and walking exercise endurance. We also aimed at evaluating possible additive effects of high-flow nasal cannula coupled with automated O titration on these outcomes.

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  • Two blood biomarkers, GFAP and UCH-L1, are being studied for their ability to indicate if elderly patients with mild traumatic brain injury (mTBI) have intracranial lesions, particularly when tested within the first 12 hours.
  • The study involves a large cohort of over 2,300 elderly patients with mTBI and aims to evaluate the effectiveness of an automated test to predict brain CT scan outcomes, and establish reference values for these biomarkers in a non-TBI elderly population.
  • Ethical approval has been secured for the research, and results will be shared at scientific meetings in the future.*
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Objective: To develop a multidisciplinary French reference that addresses initial pre- and in-hospital management of a mild traumatic brain injury patient.

Design: A panel of 22 experts was formed on request from the French Society of Emergency Medicine (SFMU) and the French Society of Anaesthesiology and Critical Care Medicine (SFAR). A policy of declaration and monitoring of links of interest was applied and respected throughout the process of producing the guidelines.

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Objectives: To describe management, and to assess factors associated with antithrombotic prescription thereafter in patients who had epistaxis referred to emergency department (ED).

Design: Prospective cohort study. From EDs, clinical, biological and hospital data were collected.

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  • The study aimed to evaluate the cost-effectiveness of different triage strategies in emergency departments (EDs) during the first wave of COVID-19, focusing on imaging methods for patients with COVID-like symptoms.
  • The retrospective analysis of 3,712 patients in five French EDs found that systematic ultra-low-dose chest CT was more cost-effective than standard chest radiography, reducing ED stay by nearly 4 hours at a minimal added cost.
  • The findings suggest that implementing systematic ultra-low-dose chest CT could enhance patient management and efficiency in EDs during health crises like the COVID-19 pandemic.
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The progression of chronic obstructive pulmonary disease (COPD) is characterized by episodes of acute exacerbation (AECOPD) of symptoms, decline in respiratory function, and reduction in quality-of-life increasing morbi-mortality and often requiring hospitalization. Exacerbations can be triggered by environmental exposures, changes in lifestyle, and/or physiological and psychological factors to greater or lesser extents depending on the individual's COPD phenotype. The prediction and early detection of an exacerbation might allow patients and physicians to better manage the acute phase.

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Purpose: Low-dose parenteral anticoagulation has demonstrated its efficacy for venous thromboembolism prophylaxis in randomized trials. However, current practice is not widely documented. In ambulatory settings, we aimed to provide an overview of the clinical use of low-dose parenteral anticoagulation in France and to assess the incidence of major bleeding and death rates.

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  • - The study compares the Hestia rule and the simplified Pulmonary Embolism Severity Index (sPESI) to determine which is better for deciding whether patients with acute pulmonary embolism can be treated at home.
  • - Conducted across 26 hospitals in multiple European countries, the research included nearly 2,000 normotensive PE patients, analyzing outcomes like recurrent thrombo-embolism and hospital discharge rates.
  • - Results showed that both triaging methods were equally safe and effective, allowing over a third of patients to be treated at home with minimal complications.
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Background: As any traumatic event, avalanches could trigger psychological disorders on survivors. Our objectives were to determine the prevalence of post-traumatic stress disorder among avalanche survivors and to evaluate post-traumatic stress disorder risks factors as well as the impact on quality of life.

Methods: A multicentre study was conducted in victims included in the North Alpine Avalanche Registry from 2014 to 2018.

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Background: Very little data are available concerning the prehospital emergency care of cancer patients. The objective of this study is to report the trajectories and outcomes of cancer patients attended by prehospital emergency services.

Methods: This was an ancillary study from a three-day cross-sectional prospective multicenter study in France.

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Background: There is little data on major muscular hematomas and the little there is has mainly focused on patients exposed to oral anticoagulants.

Objective: To describe the clinical characteristics, management and outcomes of patients admitted to emergency department (ED) for major muscular hematoma associated with an antithrombotic agent, and to identify predictors of in-hospital mortality.

Patients And Methods: Over a three-year period, all consecutive cases of adult patients admitted to the ED of 5 tertiary care hospitals for major muscular hematoma while exposed to an antithrombotic agent were prospectively collected and medically validated.

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Background: There are few reports on major gastrointestinal (GI) bleeding among patients receiving an antithrombotic.

Aim: To describe clinical characteristics, bleeding locations, management and in-hospital mortality related to these events.

Methods: Over a three-year period, we prospectively identified 1080 consecutive adult patients admitted in two tertiary care hospitals between January 1, 2013 and December 31, 2015 for major GI bleeding while receiving an antithrombotic.

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Background: Major bleedings other than gastrointestinal (GI) and intracranial (ICH) and mortality rates associated with antiplatelet drugs in real-world clinical practice are unknown. The objective was to estimate major bleeding risk and mortality among new users of antiplatelet drugs in real-world clinical practice.

Methods And Findings: A population-based prospective cohort using the French national health data system (SNIIRAM), identified 69,911 adults living within five well-defined geographical areas, who were new users of antiplatelet drugs in 2013-2015 and who had not received any antithrombotics in 2012.

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A high prevalence of intermediate cardiometabolic risk factors and obesity in chronic obstructive pulmonary disease (COPD) has suggested the existence of pathophysiological links between hypertriglyceridemia, insulin resistance, visceral adiposity, and hypoxia or impaired pulmonary function. However, whether COPD contributes independently to the development of these cardiometabolic risk factors remains unclear. Our objective was to compare ectopic fat and metabolic profiles among representative individuals with COPD and control subjects and to evaluate whether the presence of COPD alters the metabolic risk profile.

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Introduction: Hepatitis E virus (HEV) infection has been reported to be associated with neurological disorders. However, the real prevalence of acute hepatitis E in those diseases is still unknown. We determined the prevalence of anti-HEV IgM antibody in a population with acute non-traumatic, non-metabolic, non-vascular neurological injury.

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There is still debate as to the safety of non-palliative opioid administration to chronic obstructive pulmonary disease (COPD) patients punctually treated for an acute complaint. All patients over 40 presenting at two university hospital emergency departments (Montréal Qc, Grenoble Fr) from March 2008 to September 2014 with dyspnea, abdominal pain or trauma were retrieved, and COPD patients were selected. Our primary endpoint was a composite criterion including invasive ventilation and death.

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Purpose: Fatty liver disease is associated with cardiometabolic disorders and represents a potential key comorbidity in Chronic Obstructive Pulmonary Disease (COPD). Some intermediary mechanisms of fatty liver disease (including its histological component steatosis) include tissue hypoxia, low-grade inflammation and oxidative stress that are key features of COPD. Despite these shared physiological pathways, the effect of COPD on the prevalence of hepatic steatosis, and the association between hepatic steatosis and comorbidities in this population remain unclear.

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Background: Many scores derived from Early Warning Scores have been developed to detect patients at risk of poor outcome. Few of these scores incorporate the oxygen flow rate while this is a major marker in patients with respiratory complaint. We developed and evaluated a new automatable monitoring tool (Early Warning Score O: EWS.

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Objective: To develop French guidelines on the management of patients with severe abdominal trauma.

Design: A consensus committee of 20 experts from the French Society of Anaesthesiology and Critical Care Medicine (Société française d'anesthésie et de réanimation, SFAR), the French Society of Emergency Medicine (Société française de médecine d'urgence, SFMU), the French Society of Urology (Société française d'urologie, SFU) and from the French Association of Surgery (Association française de chirurgie, AFC), the Val-de-Grâce School (École du Val-De-Grâce, EVG) and the Federation for Interventional Radiology (Fédération de radiologie interventionnelle, FRI-SFR) was convened. Declaration of all conflicts of interest (COI) policy by all participants was mandatory throughout the development of the guidelines.

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