Publications by authors named "Damiano Travaglini"
Background And Aims: Crimean Congo Hemorrhagic fever virus (CCHFV) is the causative agent of Crimean-Congo hemorrhagic fever, a severe disease with a mortality rate of around 30% in humans. Previous studies demonstrate that pre-treatment with type I IFNs have an antiviral effect against CCHFV, while established CCHFV infection is almost insensitive to subsequent IFN-α treatment. No data concerning type III IFNs antiviral activity against CCHFV are available so far.
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- In early 2009, Mexico faced a rapid outbreak of a new swine-origin influenza virus (A/H1N1pdm) that quickly became a pandemic due to human-to-human transmission.
- Researchers created a new testing method targeting the nucleoprotein gene to effectively identify this unique strain, as existing molecular methods were not adequate for its distinct genetic makeup.
- This novel reverse-transcription-PCR method demonstrated better sensitivity than commercial influenza tests and accurately detected A/H1N1pdm in clinical samples, making it a reliable diagnostic tool, especially for labs without real-time PCR capabilities.
Objective: Variola virus, belonging to Orthopoxviridae family, is one of the most dangerous human pathogens that could be used as biological weapon. We have developed a new rapid assay, based upon Real-time PCR and melting temperatures analysis of amplicons, for the contemporary detection of Orthopoxvirus, VZV and HSV1-2, that are the most important infectious agents to be considered for differential diagnosis.
Methods: The target for detection of orthopoxvirus DNA has been a region of the crmB gene which is common to Variola virus and to other old world orthopoxviruses pathogenic for humans.