Publications by authors named "Damian Zhu"
Article Synopsis
- The study aimed to examine the prevalence and drug resistance of non-tuberculous mycobacteria (NTM), particularly Mycobacterium abscessus complex (MABC), in Chongqing, China, focusing on clarithromycin susceptibility.
- Researchers collected 434 patient isolates and tested them for resistance to various antibiotics, finding that 22.6% were MABC, with significant resistance patterns observed involving specific mutations.
- The findings suggest that certain genetic markers can help predict the susceptibility of MABC to macrolide antibiotics, which is crucial for treatment strategies.
Although fluoroquinolones (FQs) are the backbone drugs for the treatment of multidrug-resistant tuberculosis (MDR-TB), the knowledge about the resistance pattern and molecular characterization of new-generation FQs in Chongqing is limited. This study aimed to investigate the resistance rate and mutation types of later-generation FQs against MDR-TB in Chongqing, and further to explore the relationship between different genotypes and phenotypes. A total of 967 clinical strains were characterized using multilocus sequence typing and drug susceptibility testing, followed by analysis of genotype/phenotype association.
View Article and Find Full Text PDFBackground: Pyrazinamide (PZA) plays a unique role in the treatment for multidrug-resistant tuberculosis (MDR-TB) in both first- and second-line regimens. The aim of this study was to investigate the prevalence and molecular characterization of PZA resistance among MDR-TB isolates collected in Chongqing municipality.
Methods: A total of 133 MDR-TB isolates were collected from the smear-positive tuberculosis patients who were registered at local TB dispensaries of Chongqing.