Publications by authors named "Damian Weber"

Article Synopsis
  • Mitochondria play complex roles in two different cell death pathways: apoptosis and pyroptosis, particularly regarding NLRP3 inflammasome activation, but their exact mechanisms are not well understood.
  • The study found that activating NLRP3 while inhibiting apoptosis occurs when cells are under stress from various stimuli like nigericin and viruses, as these activators affect mitochondrial function rather than just triggering inflammasome activation.
  • NLRP3 activation needs a combination of signals—one from disrupted mitochondrial processes and another from specific NLRP3 activators—suggesting that both oxidative phosphorylation inhibition and apoptosis suppression influence cell fate.
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Foxi1 is a master regulator of ionocytes (ISCs / INCs) across species and organs. Two subtypes of ISCs exist, and both α- and β-ISCs regulate pH- and ion-homeostasis in epithelia. Gain and loss of FOXI1 function are associated with human diseases, including Pendred syndrome, male infertility, renal acidosis and cancers.

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Background: Primary flexible ureterorenoscopy (URS) and extracorporeal shock wave lithotripsy (SWL) are treatment options in patients with renal calculi of 5-15 mm.

Objective: To compare effectiveness, complication rates, and pain scores between primary URS and SWL.

Design Setting And Participants: Between 2011 and 2016, patients with renal calculi between 5 and 15 mm were randomized to undergo either primary URS or SWL.

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Background: Every day in the ICU, legal issues arise while treating sedated, unconscious, and legally incapacitated patients. Whenever a life-saving treatment cannot be discussed in a timely manner with an unconscious patient, doctors are required by law to act according to the substituted judgment standard. However, if it is not survival that is at stake, but conservation of reproduction and the potential side effects are significant, the decision-making process becomes much more difficult.

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Background: Kidney stone disease is common in industrialized countries. Recently, it has attracted growing attention, because of its significant association with adverse renal outcomes, including end stage renal disease. Calcium-containing kidney stones are frequent with high recurrence rates.

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Background: Withdrawal of oral antiplatelet therapy (OAT) is a major risk factor for stent thrombosis, myocardial infarction, and cerebral strokes. In order to minimize the risk for thrombotic complications, since 2007 robotic-assisted laparoscopic radical prostatectomy (RARP) has taken place under continuous OAT with aspirin at our institution. In this retrospective study we analyzed the risk for perioperative bleeding and surgical outcome after RARP with OAT.

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