5-HT2B receptor antagonists inhibit fibrosis and protect from RV heart failure.

Objective: The serotonin (5-HT) pathway was shown to play a role in pulmonary hypertension (PH), but its functions in right ventricular failure (RVF) remain poorly understood. The aim of the current study was to investigate the effects of Terguride (5-HT2A and 2B receptor antagonist) or SB204741 (5-HT2B receptor antagonist) on right heart function and structure upon pulmonary artery banding (PAB) in mice.

Methods: Seven days after PAB, mice were treated for 14 days with Terguride (0.