Publications by authors named "Damian L Clarke"

Introduction: Injuries account for a major portion of disability-adjusted life years in children globally, and low-and middle-income countries are disproportionally affected. While injuries due to motor vehicle collisions and self-harm have been well-characterized in pediatric populations in South Africa, injuries related to interpersonal violence (IPV) are less understood. Our study aims to characterize patterns of injury, management, and outcomes for pediatric patients presenting with IPV-related injuries in a South African trauma center.

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Article Synopsis
  • This project aims to create an electronic registry for ophthalmology in KwaZulu-Natal, South Africa, with a focus on reducing human error in prescriptions across various hospital systems.
  • A study analyzed post-operative prescriptions from cataract surgeries in 2019 and 2020 across four different state hospitals to compare prescription error rates based on the type of prescribing system used.
  • Findings indicated that higher technology usage did not lead to fewer errors but reduced the variety of errors, with electronic health records showing the lowest error rates when correcting easily identifiable mistakes; regular audits are suggested as a useful method for reducing prescription errors overall.
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Background: This multicenter study examines the contemporary management of penetrating carotid artery injury (PCAI) to identify trends in management, outcomes, and to determine prognostic factors for stroke and death.

Methods: Data from three large urban trauma centers in South Africa were retrospectively reviewed for patients who presented with PCAI from 2012 to 2020.

Results: Of 149 identified patients, 137 actively managed patients were included.

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Introduction: Pediatric laparoscopic Nissen fundoplication (LNF) has become the standard approach at many centers. We developed a minimal access surgery (MAS) training curriculum to enhance the delivery of MAS for pediatric patients in a resource-limited setting. We reviewed our 10-year experience in implementing and performing LNF at our institution.

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Unlabelled: Trauma is a leading cause of death worldwide and in South Africa. We aimed to quantify the in-hospital trauma mortality rate in Pietermaritzburg, South Africa.

Background: The in-hospital trauma mortality rate in South Africa remains unknown, and it is unclear whether deficits in hospital care are contributing to the high level of trauma-related mortality.

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Background: Despite the human immunodeficiency virus (HIV) being the most common comorbidity in South African surgical patients, its impact on appendicitis has not been well-described. We aimed to determine HIV status' influence on patients' presentation, assessment, management and outcomes with acute appendicitis.

Methods: The retrospective chart review included all patients aged 12 years and older who were HIV-positive or HIV-negative and presented with acute appendicitis between 1 January 2013 and 31 December 2019.

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Low- and middle-income countries (LMICs) have adopted procedural skill simulation, with researchers increasingly investigating simulation efforts in resource-strained settings. We aim to summarize the current state of procedural skill simulation research in LMICs focusing on methodology, clinical area, types of outcomes and cost, cost-effectiveness, and overall sustainability. We performed a comprehensive literature review of original articles that assessed procedural skill simulation from database inception until April 2022.

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Background: Trauma remains an important cause of morbidity and mortality in South Africa, but attempts to track the epidemic are often based on mortality data, or derived from individual health facilities. This project is based on the routine collection of trauma data from all public health facilities in the province of KwaZulu-Natal (KZN), between 2012 and 2022.

Methods: Hospital level data on trauma over the past ten years was drawn from the district health information system (DHIS).

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Article Synopsis
  • - The study analyzed ten years of experience with open abdomen techniques in trauma surgery, comparing a dual closure method called vacuum-assisted, mesh-mediated fascial traction (VAMMFT) to the traditional Bogota Bag (BB) method.
  • - Of 348 patients needing open abdomen management, VAMMFT had a higher closure success rate (73%) compared to BB (54.9%), but both methods had no significant differences in complications like fistulation.
  • - VAMMFT was found to be an effective and safe approach, leading to better closure rates while maintaining a low rate of complications, although failures were attributed mainly to supply issues and protocol violations.
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Introduction: Traumatic injury is a leading cause of morbidity globally, particularly in low-income and middle-income countries (LMICs). In high-income countries (HICs), it is well documented that military and civilian integration can positively impact trauma care in both healthcare systems, but it is unknown if this synergy could benefit LMICs. This case series examines the variety of integration between the civilian and military systems of various countries and international partnerships to elucidate if there are commonalities in facilitators and barriers.

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Background: Penetrating inferior vena caval injuries remain a challenging operative entity. This study reviews our local experience with the injury over a nine-year period and attempts to contextualize it within the published literature that emanates from South Africa on the topic.

Methods: A single-centre retrospective review of prospectively collected data was performed of all patients who underwent a laparotomy for a penetrating IVC injury.

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Introduction: Patients undergoing laparotomy for emergency general surgery (EGS) conditions, constitute a high-risk group with poor outcomes. These patients have a high prevalence of comorbidities. This study aims to identify patient factors, physiological and time-related factors, which place patients into a group at increased risk of mortality.

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Introduction: Patients undergoing laparotomy for emergency general surgery (EGS) have poor outcomes. Attempts have been made to improve these outcomes by adopting damage control principles known to benefit polytraumatized patients. Studies describing the use of staged laparotomy (SL) in EGS have been modest in size and heterogenous.

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Background: Most of the data on high grade Traumatic renal injuries (TRI) has come from centres which predominantly encounter blunt trauma. Blunt and penetrating mechanisms are not analogous, and it is imprudent to blindly extrapolate management strategies between the two groups. In addition, within the broad group of penetrating mechanisms of injury there are also major differences between gunshot wounds (GSW) and stab wounds (SW).

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Background: Tube thoracostomy (TT) insertion is a commonly performed procedure in trauma that is standardised, but the optimal removal technique based on the timing in relation to the respiratory cycle remains controversial.

Methods: A prospective study was undertaken at a major trauma centre in South Africa over a 4-year period from January 2010 to December 2013, and included all patients with pneumothorax secondary to thoracic stab wounds. TTs were removed by either end of inspiration technique (EIT) or end of expiration (EET) technique and the rate of recurrent pneumothorax (RPTX) following removal was compared.

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Introduction: This project aims to define the common comorbidities associated with patients undergoing emergency laparotomy in South Africa, to review the impact of these comorbidities on outcome and to attempt to model these various factors.

Method: A retrospective review of all patients undergoing emergency laparotomy for an emergency general surgical condition was performed from the prospectively entered Hybrid Electronic Medical Registry (HEMR). Univariate and multiple logistic regression analysis was performed to establish associations and independent risk factors for developing an adverse event.

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Background: South Africa is a middle-income country with major discrepancies in wealth and access to care. There is a significant burden of surgical disease and limited access to quality health care for a large proportion of the population. This article quantifies the burden of abdominal surgery over a 6-month period in KwaZulu-Natal (KZN) province and quantifies the emergency to elective (Ee) ratio for these operations.

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Background: Nontraumatic surgical emergencies constitute a significant portion of total surgical workload and are associated with a significant mortality rate. The spectrum and outcome of surgical emergencies in a low-middle-income country may differ from that in high-income countries. This study aims to describe the spectrum and outcome of emergency laparotomy for nontrauma surgical emergencies at a single-tertiary center in South Africa.

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Article Synopsis
  • The study examined the use of CT scans for pediatric trauma patients at a trauma center in South Africa, noting that over half of the children admitted received CT imaging.
  • Results indicated that many CT scans returned normal findings, with a significant portion not leading to further surgical intervention, especially in cases of head and abdominal scans.
  • The authors suggest that the high rate of CT usage and normal outcomes indicate possible over-reliance on this imaging technique in a middle-income country setting.
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Background: The phenomenon of extrajudicial "mob justice" and community assault (CA) has been documented in news reports and anecdotes from a number of low- and middle-income countries, but there is little literature on its burden on trauma systems. This study reviews a single center's management of CA victims and compares the spectrum of injuries seen following mob assault with those sustained via other forms of interpersonal violence (IPV).

Methods: Clinical data, injury details, and mortality among injured patients (age≥18) hospitalized in a South African tertiary referral center from 2012-2018 were abstracted.

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Background: While vital signs are widely obtained for trauma patients around the world, the association of these signs with surgical intervention has yet to be defined. Early detection of trauma patients requiring surgery is essential to timely intervention and reduction of morbidity and mortality.

Objective: The aim of this study was to determine the association of vital signs with surgical intervention in a South African patient population.

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Article Synopsis
  • - The PRESTO model was created to evaluate and compare the risk of death from trauma in children in low- and middle-income countries, specifically validated using data from South Africa.
  • - A study involving 1,160 injured children showed that the MIC-validated PRESTO threshold significantly outperformed the existing high-income country threshold in predicting in-hospital death.
  • - The model demonstrated better accuracy in identifying at-risk patients compared to other trauma scoring systems, emphasizing its utility in enhancing pediatric trauma care in middle-income settings.
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Introduction: We aimed to expand on the global surgical discussion around splenic trauma in order to understand locally and clinically relevant factors for operative (OP) and non-operative management (NOM) of splenic trauma in a South African setting.

Methods: A retrospective cohort study was performed using 2013-2017 data from the Pietermaritzburg Metropolitan Trauma Service. All adult patients (≥15 years) were included.

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Background: Rapid urbanization and westernization have precipitated dramatic changes in the profile and prevalence of surgical diseases in sub-Saharan Africa. Disease of lifestyle is now common. We aimed to review our experience with lower-limb amputations at our surgical service in South Africa.

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