Analysis of the and Splice Variants' Expression Profile under In Vitro Differentiation of Human Mesenchymal Bone Marrow Cells into Osteoblasts.

Bone formation is a complex process regulated by a variety of pathways that are not yet fully understood. One of the proteins involved in multiple osteogenic pathways is TID (DNAJA3). The aim of this work was to study the association of TID with osteogenesis.

The Measurement of the Oxidative Index of Polyethylene Obtained during Revision Hip Arthroplasty and Assessment of Its Variability Depending on the Degree of Osteolysis, Implantation Time, as Well as the Size and Material of the Utilized Head.

Aseptic loosening is the leading cause of late revision in total hip arthroplasty, primarily due to degenerative oxidation of polyethylene components, leading to wear particle formation and periacetabular osteolysis. This study aimed to analyze the oxidation levels in polyethylene liners and cemented cups retrieved from revision surgeries using Fourier-transform infrared spectroscopy (FTIR) and to explore the correlation between oxidation levels and factors such as head size, head material, fixation method, and implant survival time. Polyethylene liners and cups were analyzed post-revision surgery to assess oxidation levels, which were then compared to periacetabular bone loss measured by the Paprosky classification.

An Attempt to Assess the Indications for Reverse Total Shoulder Arthroplasty Based on Biomechanical Analysis.

Background: Starting from the 1950s, shoulder arthroplasty has been developing, one consequence of which has been the concept of reverse shoulder arthroplasty (RSA). Initially, it was supposed to be used only in patients with irreversible rotator cuff damage, but it quickly gained more and more indications for use. The aim of the present study was to assess biomechanical, objective indications for RSA in patients with shoulder osteoarthritis (OA) based on an inertial measurement system with electromyography.

Assessment of Microbiological and Clinical Findings of Two-Stage Revision Arthroplasty Performed Due to Prosthetic Joint Infection.

Background: Two-stage revision arthroplasty remains the main surgical strategy for the treatment of prosthetic joint infections (PJI). Sonicate fluid culture has improved sensitivity compared to standard periprosthetic tissue culture, but its usefulness is questionable during the second stage of revision arthroplasty.

Material And Methods: Twenty-seven patients with prosthetic joint infection were investigated.

Reverse Shoulder Arthroplasty in Osteoarthritis Evaluation of the Results.

Background: The aging structure of society results in a growing need for treatment of shoulder osteoarthritis. Reverse shoulder arthroplasty (RSA) has been developed to improve the motor function and strength of the shoulder joint without increasing the risk of dislocation. The aim of the study was to assess the change in quality of life and functional assessment of the shoulder joint after RSA in patients with osteoarthritis, based on the Oxford Shoulder Score (OSS) and an assessment of joint mobility parameters.

Pseudotumor as a Complication of Total Hip Replacement.

Total hip arthroplasty with metal-on-metal bearing is associated with specific complications: local delayed hypersensitivity reaction (ALVAL) to metal particles, osteolysis and the development of pseudotumors. This process results from the low resistance of the metal bearing to abrasion and corrosion, which causes the release of metal ions into the surrounding tissues. This paper presents the case of a 54-year-old man who required revision surgery due to aseptic loosening of the endoprosthesis with a ceramic (TiN)-on-metal bearing.

Chronic, Neglected Medial Subtalar Dislocation with Associated Talar and Calcaneal Fractures. A Case Report.

Subtalar dislocation is a very rare injury that accounts for just approximately 1% of traumatic dislocations. Stan-dard treatment in acute subtalar dislocations is immediate closed reduction and cast immobilization. Early reduction is of key importance and allows avoiding further damage to soft tissues, nerves and blood vessels.

The electromyographic activity characteristics of the gluteus medius muscle before and after total hip arthroplasty.

Purpose: The clinical outcomes of total hip arthroplasty are influenced by the correct muscle function that determines good, longterm and proper function of the artificial joint. The aim of the study was to analyze the electromyographic activity of the gluteus medius muscle in patients with hip osteoarthritis and after arthroplasty in various static weight bearing conditions, both on the affected and contralateral side.

Methods: The prospective study involved 70 patients qualified for hip replacement.

Differences between sexes in the standard and advanced dimensioning of lateral meniscal allografts.

Background: There are many different methods of meniscal allograft measurements, which depend on individual tissue bank procedures. Due to the lack of a standardised method of dimensioning, measurement results may vary between individual cases. Consequently, allograft may be mismatched to the patient's knee anatomy.

Correction to: Atraumatic femoral neck fracture during bisphosphonate treatment: case report and review of the literature.

Correction to: Aging Clin Exp Res https://doi.org/10.1007/s40520-017-0846-0.

Notch signaling pathway and gene expression profiles during early in vitro differentiation of liver-derived mesenchymal stromal cells to osteoblasts.

Notch signaling is a key signaling pathway for cell proliferation and differentiation. Therefore, we formulated a working hypothesis that Notch signaling can be used to detect early osteoblastic differentiation of mesenchymal stromal cells. Changes in expression and distribution of Notch 1, 2, 3, and Delta1 in the cytoplasm and nuclei of rat liver-derived mesenchymal stromal cells differentiating into osteoblasts were investigated, together with the displacement of intracellular domains (ICDs) of the receptors.

Factors Influencing Treatment of Proximal Femoral Fractures.

Background: Orthopaedics and traumatology departments are dominated by patients with proximal femoral fractures, who represent 20-30% of all patients treated there. The aim of this study was identification and evaluation of factors influencing treatment of proximal femoral fractures.

Material And Methods: Between 2008 and 2015, we treated 424 femoral neck fractures and 442 trochanteric fractures in patients over 40 y/o.

The 13-year observation of hip fracture in Poland-worrying trend and prognosis for the future.

Introduction: Hip fractures are often considered to be one of the most common osteoporotic fractures. In our previous study, we noted the increasing trend in the total number of hip fractures as well as crude and standardized rates, for both women and men. This observation enabled us to delve deeper into the study of osteoporotic fractures.

Identification of Asymptomatic Prosthetic Joint Infection: Microbiologic and Operative Treatment Outcomes.

Background: This prospective study investigated the role of mechanical and biological factors in aseptic implant loosening or presumed silent prosthetic joint infection (PJI).

Methods: Thirty-seven patients were investigated. Microbiologic and molecular methods were used to detect bacteria on the surface of the failed implants removed during revision arthroplasty.

Osteitis in the Course of Pyodema Gangrenosum. Case Raport.

We present the case of a male patient admitted to the Department of Orthopaedics and Musculoskeletal Traumatology, Medical University of Silesia (MUS) in Katowice, due to a right hindfoot abscess with calcaneal infiltration and pain in the forehead and the back, with evidence of local inflammation. The patient had a history of ulcerative colitis and sclerosing cholangitis was suspected. During the hospital stay, the patient underwent calcaneal CT, surgery (resection of an inflammatory focus) and MRI of the thoracic and lumbosacral spine, which revealed inflamed spinous processes of the Th10, Th11 and Th12 vertebrae.

Variation in the Posterior Condylar Angle.

Background: Clinical success of TKR depends to a large extent on the correct positioning of the implants. The femur cut is usually made in 3° of external rotation relative to the posterior aspect of the femoral condyles, which is a typical value of the Posterior Condylar Angle (PCA). The aim of this study was to assess variation in the PCA and to identify possible correlations between the value of the PCA and the following parameters: gender, body side, body height and weight (BMI).

Kinematic gait parameters changes in patients after total knee arthroplasty. Comparison between cruciate-retaining and posterior-substituting design.

Purpose: The patients expect optimal knee function after Total Knee Arthroplasty. It is necessary to apply appropriate surgical technique and supervised physical therapy. The optimal management of posterior cruciate ligament remains controversial.

Do we need orthogeriatrics in Poland? Changes in the age structure and location of hip fractures.

Background: Patients with hip fractures present a great challenge for surgeons due to multimorbidity, polypharmacy as well as difficulty in communicating. These could be attributed to a recent trend in the aging patient population (80 years and older) as compared to the past. The aim of this study is to analyze age structure and location in male and female patients' population with hip fracture over 50.

Medical and Economic Advantages of Postoperative Blood Salvage in Total Knee Replacement.

Background: Total knee replacement surgery causes large blood loss leading to worsening of the patient's physical capacity, difficulties in rehabilitation and necessity of transfusions. The re-infusion of drainage fluid has been described as an alternative way to improve hematological parameters. The aim of the study was to determine the effectiveness of re-transfusion with regard to the allogeneic transfusion rate, duration of treatment and costs.

Comparison of cultures and 16S rRNA sequencing for identification of bacteria in two-stage revision arthroplasties: preliminary report.

Background: The use of a prefabricated spacer in two-stage revision arthroplasty remains one of the few surgery strategies for infected-joint arthroplasty treatment, despite the many unidentified microorganisms in the infected joint replacements reported in some recent studies. The aim of this prospective survey was to investigate if the sonication followed by polymerase chain reaction (PCR) can improve bacterial identification on the surfaces of prefabricated spacers and if the systemic laboratory mediators of infection and positive microbiological results can take a role of predictive factors of infection and clinical failures in 2-years follow-up.

Methods: Thirteen patients with prosthetic joint infection were investigated.

Radiological Evaluation of Treatment of Periprosthetic Femoral Fractures.

Background: Periprosthetic fracture of the femur is a common complication of total hip replacement surgery. There are several risk factors, including the female gender, an uncemented implant, the use of a straight or revision stem and secondary osteoarthritis. The aim of the study was a radiological evaluation of treatment of periprosthetic femoral fractures Material and methods.

Gait analysis in patients after unilateral hip arthroplasty.

Background: Osteoarthritis (OA) is the most common joint pathology and the main cause of disability in elderly persons. Arthroplasty still remains the most effective treatment of OA. Routine post-operative patient assessment does not include an objective functional examination leading to conclusions regarding the need of further rehabilitation.

Novel bioactive polyester scaffolds prepared from unsaturated resins based on isosorbide and succinic acid.

In this study new biodegradable materials obtained by crosslinking poly(3-allyloxy-1,2-propylene succinate) (PSAGE) with oligo(isosorbide maleate) (OMIS) and small amount of methyl methacrylate were investigated. The porous scaffolds were obtained in the presence of a foaming system consisted of calcium carbonate/carboxylic acid mixture, creating in situ porous structure during crosslinking of liquid formulations. The maximum crosslinking temperature and setting time, the cured porous materials morphology as well as the effect of their porosity on mechanical properties and hydrolytic degradation process were evaluated.