Publications by authors named "Damian Kusmirek"
Article Synopsis
- OATD-02 is a newly developed oral drug that inhibits arginases 1 and 2 (ARG1 and ARG2), which are enzymes linked to immune regulation in cancer.
- The drug shows strong potential to combat tumor-related immune suppression and improve the effectiveness of other cancer treatments.
- Nonclinical studies suggest that OATD-02 has favorable pharmacologic properties, making it a promising candidate for clinical trials in cancer patients.
This work presents results of methyl 7-oxoabiet-13(14)-en-18-oate (3) self-oxidation with air-oxygen in the presence of various bases such as triethylamine or sodium t-butoxide. While under aerobic conditions, the use of sodium t-butoxide as a base results in the formation of four isomeric alcohols, an addition of triethylamine into reaction medium directs the enone 3 oxidation to hydroperoxides. To clarify this base dependence and to obtain more in-depth information about this reaction additional studies with cyclohexenone as a reference enone have been undertaken.
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