Experts vs. machine - comparison of machine learning to expert-informed prediction of outcome after major liver surgery.

Background: Machine learning (ML) has been successfully implemented for classification tasks (e.g., cancer diagnosis).

P-value based analysis for shared controls design in genome-wide association studies.

An appealing genome-wide association study design compares one large control group against several disease samples. A pioneering study by the Wellcome Trust Case Control Consortium that employed such a design has identified multiple susceptibility regions, many of which have been independently replicated. While reusing a control sample provides effective utilization of data, it also creates correlation between association statistics across diseases.