Publications by authors named "Damia Akimori"

, commonly known as the human threadworm, is a skin-penetrating gastrointestinal parasitic nematode that infects hundreds of millions of people worldwide. Like other species, is capable of cycling through a single free-living generation. Although and the free-living nematode are evolutionarily distant, the free-living adults of are similar enough in size and morphology to adults that techniques for generating transgenics and knockouts in have been successfully adapted for use in .

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Article Synopsis
  • Strongyloides stercoralis is a parasitic nematode that causes strongyloidiasis, a neglected tropical disease linked to chronic illness and deaths.
  • Researchers have developed a method to create stable transgenic lines of S. stercoralis, which improves upon existing techniques that struggled with inconsistent expression across generations.
  • This new transgenesis approach will facilitate more in-depth studies of parasite biology, allowing comparisons between free-living and parasitic stages of development.
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The RNA-seq Browser is an open-source Shiny web app that enables on-demand visualization and quantification of bulk RNA-sequencing data for five species: , , , , and . The app is designed to allow researchers without previous coding experience to interactively explore publicly available RNA-sequencing data. Key app features include the ability to plot gene expression across life stages for user-specified gene sets, and modules for performing differential gene expression analyses.

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Advances in the functional genomics and bioinformatics toolkits for species have positioned these species as genetically tractable model systems for gastrointestinal parasitic nematodes. As community interest in mechanistic studies of species continues to grow, publicly accessible reference genomes and associated genome annotations are critical resources for researchers. Genome annotations for multiple species are broadly available via the WormBase and WormBase ParaSite online repositories.

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