Patterning Perfluorinated Surface with Graphene Oxide and the Microarray Applications.

A method was developed to pattern the surface of perfluorinated materials with graphene oxide thin film, and various biological applications of the patterned perfluorinated surface were illustrated. Perfluorinated surfaces such as Teflon, Cytop, and other perfluorinated materials are known to be both hydrophobic and oleophobic, with low adhesion for most materials. Modifying the perfluorinated surfaces has been difficult due to the extraordinary chemical inertness, which limits the applications of perfluorinated materials as anti-fouling substrates.

Novel Substrates for Microarrays.

In the microarray platform, the surface substrate is critical to the result quality in terms of signal consistency and detection sensitivity. Traditional substrates such as glass and nitrocellulose often entail complicated preparation processes such as the activation and functionalization of the reaction spots and surface blocking to prevent nonspecific molecule adsorption. In addition, coffee-ring morphology of the spots is a common issue in the traditional substrates.

Synchronization of Coupled Oscillators on a Two-Dimensional Plane.

The effect of the transfer rate of signal molecules on coupled chemical oscillators arranged on a two-dimensional plane was systematically investigated in this paper. A microreactor equipped with a surface acoustic wave (SAW) mixer was applied to adjust the transfer rate of the signal molecules in the microreactor. The SAW mixer with adjustable input powers provided a simple means to generate different mixing rates in the microreactor.

Accelerating the "On Water" Reaction: By Organic-Water Interface or By Hydrodynamic Effects?

A series of organic reactions proceed dramatically faster in a heterogeneous mixture of the reactants and water than in a homogeneous mixture. Currently it is unclear whether the rate acceleration is due to the free OH groups at the organic-water interface, or due to the hydrodynamic effects caused by vigorous stirring, vortexing, or ultrasonication. Herein we produced static droplets in microfluidic devices to answer this question.

A microreactor and imaging platform for studying chemical oscillators.

We present a laser scanning confocal microscopy (LSCM) and continuous flow microreactor (CFMR)-based platform to study the Belousov-Zhabotinsky (BZ) oscillators. We demonstrated that the scanning laser light below a certain power had no detectable influence on the BZ reaction. The CFMR consisted of the poly(methyl methacrylate) (PMMA) microwell and the polydimethylsiloxane (PDMS) microchannel and maintained the oscillation with a continuous supply of the catalyst-free BZ mixture.

Single-chain polymers achieved from radical polymerization under single-initiator conditions.

Radical polymerization from a single initiator molecule in a microenvironment is a nearly ideal system in which bimolecular termination, solution concentration, and viscosity changes could be neglected. In this study, we provide two facile methods of preparing polymers via atom-transfer radical polymerization (ATRP) under single-initiator conditions: tether initiators on planar substrates at superlow density through mixed self-assembled monolayers (SAMs) and encapsulated single initiators in microfluidic droplets. The molecular weight (MW) of the resultant polymers characterized by atomic force microscope-based single-molecule force spectroscopy (AFM-based SMFS) showed that the single-chain ATRP had an extraordinarily faster chain propagation rate (2 unit/s) on planar substrates and gave polymers with much higher MWs (10(5)-10(6) g/mol) than those obtained from traditional ATRP (10(3)-10(5) g/mol).