Modulation of Drug Resistance by Furanochromones in Overexpressing .

Khellin and visnagin are natural furanochromones that photoreact with DNA. Khellin has been used in the treatment of vitiligo and psoriasis, as well as in the treatment of angina pectoris and asthma due to its potent action as a coronary vasodilator and antispasmodic agent. The present study aimed to investigate whether the compounds khellin and visnagin act as inhibitors of NorA protein, an efflux pump overproduced by the strain of SA-1199B that confers resistance to the fluoroquinolones, such as norfloxacin and ciprofloxacin.