Publications by authors named "Damak M"

In recent years, the environmental impacts of plastic production and consumption have become increasingly significant, particularly due to their petroleum-based origins and the substantial waste management challenges they pose. Currently, global plastic waste production has reached 413.8 million metric tons across 192 countries, contributing notably to greenhouse gas emissions.

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Multiple sclerosis (MS) can induce cardiac autonomic dysfunction identified by a decreased heart rate variability (HRV) which was linked to oxidative stress, vitamin D deficiency and sleep disturbance. Previous MS studies revealed the antioxidant and anti-inflammatory effects of exogenous melatonin, as well as its benefits on sleep and vitamin D. We aimed to investigate the change in HRV, oxidative stress, systemic inflammation and sleep following melatonin supplementation in MS patients.

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Studying the effects of self-paced concurrent high-intensity interval training and resistance training (HIIT-RT) on respiratory function, cardiopulmonary fitness and fatigue perception in patients with multiple sclerosis (PwMS). Twenty-three PwMS were randomized into a 12-week training group (three times per week) (TG, n = 11) or a control group (CG, n = 12). Lung function (spirometry), aerobic capacity (graded cardiopulmonary-exercise-testing) and perceived fatigue (Fatigue Severity Scale (FSS)) were evaluated pre- and post-intervention.

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Article Synopsis
  • Persons with multiple sclerosis (PwMS) often face issues like sleep disturbances, fatigue, and pain, which can affect their balance and walking, potentially increasing fall risk.
  • This study investigated the long-term effects of chronic melatonin supplementation on PwMS, comparing a melatonin group with a placebo group over 12 weeks.
  • Results showed improvements in dynamic postural stability, walking performance, sleep quality, fatigue perception, and neuropathic pain in the melatonin group, suggesting it could be beneficial for managing symptoms in PwMS.
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Introduction: Ischemic Stroke in young adults is a real public health problem; it's a major cause of disability, alters quality of life and has a great socio-economic impact.

Aim: determine risk factors and specify the etiology of arterial ischemic stroke in young Tunisian adults.

Methods: In this 5 years retrospective study (2015-2020), we included all young adults (18-50 years) admitted for arterial ischemic stroke (AIS).

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Article Synopsis
  • Reports of side effects from COVID-19 vaccinations, particularly cases of autoimmune diseases like chronic inflammatory demyelinating polyneuropathy (CIDP) and Guillain-Barré syndrome (GBS), are increasing, though the exact relationship with vaccines is still debated.* -
  • A case study from Tunisia involves a 41-year-old man who developed CIDP after receiving the Oxford/AstraZeneca vaccine, presenting symptoms 15 days post-vaccination and initially misdiagnosed as GBS.* -
  • The need for awareness of CIDP as a potential post-vaccination complication is emphasized to ensure appropriate treatment and prevent long-term issues, especially since cases linked to the AstraZeneca vaccine appear to be more common.*
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Background: Decreased endogenous melatonin concentrations in people with multiple sclerosis (PwMS) are associated with fatigue and pain that impair postural balance and muscle strength. Melatonin ingestion had analgesic and anti-fatigue effects. However, the acute effect of exogenous melatonin on dynamic postural stability and muscle strength has not been studied yet in PwMS.

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The current energy crisis and waste management problems have compelled people to find alternatives to conventional non-renewable fuels and utilize waste to recover energy. Pyrolysis of plastics, which make up a considerable portion of municipal and industrial waste, has emerged as a feasible resolution to both satisfy our energy needs and mitigate the issue of plastic waste. This study was therefore conducted to find a solution for plastic waste management problems, as well as to find an alternative to mitigate the current energy crisis.

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  • The study reaffirms the role of intrathecal B cell response, especially IgG oligoclonal bands (OCB), in diagnosing multiple sclerosis (MS) according to revised criteria.
  • New B cell-related molecules, including free light chains (FLCκ and λ) and CXCL13, were tested in cerebrospinal fluid (CSF) samples to improve diagnostic accuracy.
  • Results indicate that FLC metrics and CXCL13 levels were higher in MS patients, with the κFLC index showing the best diagnostic performance, although OCB detection remains essential.
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The protein phosphatase 2A complex (PP2A), the major Ser/Thr phosphatase in the brain, is involved in a number of signalling pathways and functions, including the regulation of crucial proteins for neurodegeneration, such as alpha-synuclein, tau and LRRK2. Here, we report the identification of variants in the PTPA/PPP2R4 gene, encoding a major PP2A activator, in two families with early-onset parkinsonism and intellectual disability. We carried out clinical studies and genetic analyses, including genome-wide linkage analysis, whole-exome sequencing, and Sanger sequencing of candidate variants.

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Emulsions are widely used in agriculture where oil-based pesticides are sprayed as an emulsion. However, emulsion droplets can bounce off hydrophobic plant surfaces, leading to major health and environmental issues as pesticides pollute water sources and soils. Here, we report an unexpected transition from bouncing to sticking to bouncing as the droplet impact speed increases.

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Objectives: We aimed to assess and compare autonomic function in Parkinson's disease (PD) associated with the leucine-rich repeat kinase (LRRK2) G2019S mutation (LRRK2-PD) and non-LRRK2 PD, by the study of heart rate variability (HRV) and sympathetic skin responses (SSR).

Methods: In a cross-sectional three-year study, fifty LRRK2-PD and fifty clinically matched non-LRRK2 PD patients were included. Cardiac parasympathetic functions were assessed using heart rate variation to deep breathing (HR-DB), to the Valsalva maneuver (HR-V) and to standing (HR-S) and the sympathetic autonomic system by sympathetic skin responses (SSR).

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Objective: The Islamic Republic of Iran has displayed one of the highest rates of COVID-19 infection in the world and the highest rate of mortality in the Middle East. Iran has used a stringent package of preventive health measures to mitigate the spread of infection, which however has negatively affected individuals' physical and psychological health. This study aimed at examining whether physical-activity (PA) behavior, anxiety, well-being, and sleep-quality changed in response to the COVID-19-related public health restrictions enforced in Iran.

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Background: Since the SARS-CoV-2 pandemic has started in December 2019, millions of people have been infected all over the world. Vaccination is the most efficient tool to end this pandemic, but vaccine surveillance is necessary to identify side effects. Some studies have shown that neurological complications after COVID-19 vaccination are rare and dominated by demyelinating disease.

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An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Article Synopsis
  • Cerebrovascular accidents (strokes) are significant public health issues due to their high prevalence and various social, medical, and economic impacts, prompting a study to identify survival prognostic factors.
  • A prospective study was conducted over four months involving 200 stroke patients at two University Hospitals in Tunisia, revealing a 19.9% mortality rate after one month and multiple poor prognostic factors such as male sex, tobacco use, and severe neurological deficits.
  • Identifying these prognostic factors is crucial for improving treatment approaches and patient management; future research will further evaluate the effectiveness of proposed corrective measures.
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The ability of mixing colors with remarkable results had long been exclusive to the talents of master painters. By finely combining colors in different amounts on the palette, intuitively, they obtain smooth gradients with any given color. Creating such smooth color variations through scattering by the structural patterning of a surface, as opposed to color pigments, has long remained a challenge.

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Offshore fish farms have been active inside the Monastir Bay, Hammemet Gulf for over 10 years, but their environmental impact is still unknown. This study focuses on the evaluation of the fish farming activity impact in the Monastir Bay as revealed by geochemical and benthic foraminiferal data. Samples were collected around three fish cages at different water depths.

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To investigate the current environment status in Monastir Bay (Tunisia), surface sediments from 32 stations were assessed for heavy metal and organic matter concentrations, and the results were compared with values of natural metal content, marine sediment quality standards, and other results concerning sediments from other Mediterranean coasts. The study of their spatial distributions refined by complementary approaches, including potential ecological risks determined through the enrichment factor, geo-accumulation index, contamination factor, potential ecological risk index, pollution load index, and principal component analysis, showed a significant impact of multiple anthropogenic sources. Moderate pollution of sediments, particularly by Ni and Cu, was also observed.

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Context: After primary infection, varicella zoster virus (VZV) becomes latent in ganglionic neurons. If immunity declines, VZV is reactivated and can spread to the dermatome depending from this ganglion and in some cases to the spinal cord. Myelopathy is rare and may develop in the absence of skin rash making the diagnosis very difficult.

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