Background: Post-rest contraction (PRC) of cardiac muscle provides indirect information about the intracellular calcium handling.
Objective: Our aim was to study the behavior of PRC, and its underlying mechanisms, in rats with myocardial infarction.
Methods: Six weeks after coronary occlusion, the contractility of papillary muscles (PM) obtained from sham-operated (C, n=17), moderate infarcted (MMI, n=10) and large infarcted (LMI, n=14) rats was evaluated, following rest intervals of 10 to 60 seconds before and after incubation with lithium chloride (Li(+)) substituting sodium chloride or ryanodine (Ry).