Publications by authors named "Dalong Shu"
Article Synopsis
- The study aims to create a risk signature based on cholesterol-related genes to improve prognosis prediction for head and neck squamous cell carcinoma (HNSCC), which is known for its aggressive nature and poor response to treatments.
- Utilizing datasets from The Cancer Genome Atlas and Gene Expression Omnibus, researchers developed and validated this risk signature across various cohorts, enhancing clinical decision-making with a nomogram model that includes key cholesterol-related genes.
- Key findings indicate that the constructed risk signature effectively predicts clinical outcomes for HNSCC patients by identifying significant genes involved in cholesterol metabolism, with additional experimental validation through cell line studies.
Background: Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent malignancies worldwide and is characterized by unfavorable prognosis, high lymph node metastasis and early recurrence. However, the molecular events regulating HNSCC tumorigenesis remain poorly understood. Therefore, uncovering the underlying mechanisms is urgently needed to identify novel and promising therapeutic targets for HNSCC.
View Article and Find Full Text PDFObjective: To assess the accuracy of half-way digital mucosa-supported implant guides (HDMIGs) for edentulous jaws.
Methods: Ninety-five consecutive patients (859 implants) with edentulous jaws who underwent implant placement using an HDMIG from July 2012 to June 2018 were retrospectively identified. The primary endpoint was implant-related complications (nerve injury and unexpected perforation), and the secondary endpoints were the faciolingual distance, mesiodistal distance, buccolingual angle, and mesiodistal angle.
BACKGROUND The association of periodontitis (PD) with the prevalence of rheumatoid arthritis (RA) remains controversial. Therefore, the aim of this study was to evaluate their correlation and investigate the effects of non-surgical periodontal treatment on RA. MATERIAL AND METHODS A total of 64 patients were enrolled in this study and divided into 4 groups: 18 PD patients (PD+RA-), 18 RA patients (PD-RA+), 18 RA with PD patients (PD+RA+), and 10 healthy controls (PD-RA-).
View Article and Find Full Text PDFBackground: This study aimed to evaluate the accuracy of surgical outcomes in free iliac crest mandibular reconstructions that were carried out with virtual surgical plans and rapid prototyping templates.
Methods: This study evaluated eight patients who underwent mandibular osteotomy and reconstruction with free iliac crest grafts using virtual surgical planning and designed guiding templates. Operations were performed using the prefabricated guiding templates.
Purpose: This study sought to introduce 3-dimensional (3D) virtual surgical planning and digital rapid-prototyping templates for zygomaticomaxillary complex (ZMC) injuries associated with orbital volume change and to evaluate the surgical outcomes quantitatively.
Patients And Methods: Eight patients who underwent open reduction and fixation for a ZMC injury with orbital volume change were studied. Computed tomographic (CT) scan of the zygomaticomaxillary area was performed before the operation in each case.
Tacrolimus on Kimura's disease: a case report.
Oral Surg Oral Med Oral Pathol Oral Radiol
February 2014
Objective: We report preliminary results of an ongoing study that assesses the efficacy of tacrolimus on Kimura's disease (KD).
Study Design: A patient with refractory KD after surgery and treatment with prednisone was treated with tacrolimus. Tacrolimus (FK-506) was administered at an initial dosage of 1 mg every 12 hours, and FK-506 concentration in the blood was monitored monthly.
Article Synopsis
- * Thirty-six titanium implants were placed in the mandibles of nine beagles and monitored for stability and bone integration over 12 weeks using various analytical methods.
- * Results showed that MAO-treated implants led to significantly greater bone contact and strength compared to untreated implants, indicating quicker and stronger osseointegration.
Removal of a foreign body from the skull base using a customized computer-designed guide bar.
J Craniomaxillofac Surg
June 2010
Background: Foreign bodies located at the base of the skull pose a surgical challenge. Here, a customized computer-designed surgical guide bar was designed to facilitate removal of a skull base foreign body.
Methods: Within 24h of the patient's presentation, a guide bar and mounting platform were designed to remove a foreign body located adjacent to the transverse process of the atlas and pressing against the internal carotid artery.