Adjuvant radiotherapy for Merkel cell carcinoma: A systematic review and meta-analysis.

Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignancy with a high propensity for local recurrence and regional and distant metastases. The main treatment is surgery with narrow excision margins and draining nodes, plus or minus adjuvant radiotherapy (RT) on the surgical bed and/or lymph nodes. We performed a systematic review and meta-analysis of the benefits of adjuvant RT in MCC treatment.

Prognostic value of diffuse versus intestinal histotype in patients with gastric cancer: a systematic review and meta-analysis.

Background: There are two distinct types of gastric carcinoma (GC), intestinal, more frequently sporadic and linked to environmental factors, and diffuse (undifferentiated) that is highly metastatic and characterized by rapid disease progression and a poor prognosis. However, there are many conflicting data in the literature concerning the association between histology and prognosis in GC. This meta-analysis was performed to provide demonstration if histology according to Lauren classification is associated with different prognosis in patients with GC.

Prognostic Survival Associated With Left-Sided vs Right-Sided Colon Cancer: A Systematic Review and Meta-analysis.

Importance: Primary tumor location is emerging as an important prognostic factor owing to distinct biological features. However, the side of origin of colon cancer (CC) still does not represent a prognostic parameter when deciding for adjuvant or palliative chemotherapy.

Objective: To determine the prognostic role of left vs right-sidedness of primary tumor location in patients with CC.

[Surgical treatment of Crohn's disease. Indication and management in 20 patients].

Materials And Methods: Sixty-seven patients with Crohn's disease underwent surgery in our department in the period 1989-1996. In this paper we evaluated only the first 20 patients. Ten were female and 10 male.

[Expanding lesions of the orbit: Multicase review].

Different types of neoplastic and non neoplastic lesions can affect the orbit causing ocular damage. Aim of the present study was that to review a series of endoorbital neoplastic and non neoplastic space occupying lesions. All the cases of endoorbital lesions, seen during the period January 1980-September 1996, were retrieved from the files of the Department of Pathology of the Ospedale Bellaria of Bologna (Italy).

[Personal experience in the treatment of intestinal carcinoids].

The authors report 7 cases of intestinal carcinoids. They examine the clinical aspects and describe and discuss both surgical and medical treatment strategies. They also critically evaluate the value of monitoring some oncological markers and their prognostic significance.

Ameloblastic fibroma: a follow-up of six cases.

Six cases of ameloblastic fibroma of the jaw are reported, and the radiographic and histologic features and clinical symptoms are described. A conservative surgical approach, including enucleation and mechanical curettage of the surrounding bone, appeared to be successful for these patients.

[pT1G3 tumor of the bladder].

The management of the superficial bladder tumor is commonly performed by transurethral resection (TUR) and a following chemotherapy or immunotherapy with exception of Tis. A lot of doubts and questions raise in the management of pT1G3 bladder tumor (BT) for the high grade of recurrencies and progressions. Our experience from 1984 to 1994 about 109 patients (pts) with pT1G3 BT undergone to radical cystectomy (47 pts) and TUR (62 pts) allows us to state that when Tis is present a radical cystectomy is mandatory, but the TUR option must be followed to frequent and accurate random biopsies in order to discovery foci of Tis.

Ameloblastic fibrosarcoma of the jaw: report of five cases.

Five cases of ameloblastic fibrosarcomas (AFS) are reported. The tumour was characterized histologically by a biphasic pattern: the malignant mesenchymal component had the features of an intermediate grade fibrosarcoma in 3 cases, malignant fibrous histiocytoma and osteogenic sarcoma in 2 cases. The epithelial odontogenic component had a benign appearance cytologically.

Local capsular dissection of parotid pleomorphic adenomas.

Local capsular dissection as described by HANCOCK11 for the treatment of parotid pleomorphic adenomas is discussed. The results of 71 primary parotid pleomorphic adenomas are described, including a 5.6% recurrence rate.

The Istituto Rizzoli-Beretta experience with osteosarcoma of the jaw.

Twenty-eight osteosarcomas (OS) of the jaw were reported. There were 15 male and 13 female patients (age range, 9 to 68 years; mean, 36.9 years); 57.

[Pre- and postoperative radiotherapy of oral carcinoma of a locally advanced stage. An analysis of the results and complications].

The combination of radiotherapy and surgery in the treatment of advanced oral carcinoma (T3 and T4 lesions) yields good possibilities of recovery; whether radiotherapy should be given before or after surgery is still debated. Fifty patients with advanced oral carcinomas were analyzed: 24 of them were irradiated before and 26 after surgery; doses ranged from 40 to 56 Gy for the first group of patients, and from 50 to 68 Gy for the second one. The disease-free survival 48 months after the diagnosis was 36% in patients who received preoperative irradiation, and 53.

[Incidence of lymph node metastases in epithelial neoplasms of the oral cavity: risk factors].

The incidence of pathological neck nodes metastases in a group of 60 patients with a diagnosis of oral squamous carcinoma is reviewed. Risk factors are a size of primary more than 4 cm and tumors of the anterior two-third of the tongue. Carcinomas of oral tongue, also of a size less than 4 cm (T1,T2), have a high incidence of subclinical metastases.

[Myxomas of the jaws. 10 cases and differential diagnostic evaluations].

Ten cases of myxoma of the jaw bones are presented. After an examination of the anatomical-clinical-radiological aspects and the micro- and macroscopic pathological anatomy, the authors present a histopathological differential diagnosis and in particular demonstrate that a diagnosis of myxoma is based upon its localization and the exclusion of any benign and malignant lesions due to myxoid. Conservative excision is the preferred treatment.