Publications by authors named "Dallas Larsen"
Article Synopsis
- The text discusses the genomic research on a highly nutritious plant known as garden orach, highlighting its physiological characteristics and historical significance as a food source.
- Researchers developed the first complete chromosome-scale reference genome for the "Golden" cultivar using advanced sequencing technologies, resulting in a high-quality assembly with significant levels of repetitive DNA.
- The genome annotation revealed over 37,000 gene models, indicating a comprehensive understanding of its genetic structure, but highlighted a lack of prior genetic data to fully explore the species' potential.
Introduction: The purpose of this study was to examine the effects of elevated Hypoxanthine Guanine Phosphoribosyltransferase (HPRT) on the immune response in the tumor microenvironment.
Methodology: HPRT expression was evaluated in cancer patients and correlated with cytokine expression, survival, and immune cell infiltration. An HPRT knockdown cell line was created to evaluate HPRT impact on purine expression and subsequent purine treatment was administered to immune cells to determine their influence on cell activation.
Background: The Critical Assessment of Functional Annotation (CAFA) is an ongoing, global, community-driven effort to evaluate and improve the computational annotation of protein function.
Results: Here, we report on the results of the third CAFA challenge, CAFA3, that featured an expanded analysis over the previous CAFA rounds, both in terms of volume of data analyzed and the types of analysis performed. In a novel and major new development, computational predictions and assessment goals drove some of the experimental assays, resulting in new functional annotations for more than 1000 genes.