Diet induced insulin resistance is due to induction of PTEN expression.

Type 2 Diabetes (T2D) is a condition that is often associated with obesity and defined by reduced sensitivity of PI3K signaling to insulin (insulin resistance), hyperinsulinemia and hyperglycemia. Molecular causes and early signaling events underlying insulin resistance are not well understood. Insulin activation of PI3K signaling causes mTOR dependent induction of PTEN translation, a negative regulator of PI3K signaling.

Restoring jawline contour with calcium hydroxylapatite: A prospective, observational study.

Background: Jawline reshaping by replacing volume has become an indispensable component of modern facial rejuvenation.

Aim: To evaluate calcium hydroxylapatite (CaHA) for the treatment of an aging jawline in a routine setting.

Methods: Five investigators enrolled 35 subjects requesting jawline rejuvenation with CaHA.

Calcium hydroxylapatite for jawline rejuvenation: consensus recommendations.

Background: Age-associated volume loss is now known to play an important role in the structural changes of the aging face. In the lower face, this manifests as drooping of the corners of the mouth and jowl leading to a loss of the oval jawline of youth. Jawline reshaping by replacing volume has therefore become an indispensable component of modern facial rejuvenation.

Clinical equivalence of conventional OnabotulinumtoxinA (900 KDa) and IncobotulinumtoxinA (neurotoxin free from complexing proteins - 150 KDa): 2012 multidisciplinary French consensus in aesthetics.

Botulinum neurotoxins are the most popular non-surgical treatments for aesthetic indications, but there is uncertainty about whether certain formulations are comparable in efficacy and safety and can be substituted for one another by a simple one to one dose conversion ratio. An expert panel of French practitioners was convened to establish a consensus on the clinical equivalence in efficacy and safety of OnabotulinumtoxinA (900 KDa) and IncobotulinumtoxinA (neurotoxin free from complexing proteins - 150 KDa). The consensus was divided into three sections incorporating a biological, bibliographic and clinical analysis of the two toxins.

A prospective, noninterventional study of the treatment of the aging hand with Juvéderm Ultra® 3 and Juvéderm ® Hydrate.

Background: Hand rejuvenation aims to restore volume and produce smooth, elastic skin. A combined treatment has been proposed: Juvéderm Ultra® 3 for filling and smoothing the skin and Juvéderm® Hydrate to rehydrate and restore skin quality.

Methods: Twenty physicians enrolled 99 subjects (i.

Upper- and mid-face anti-aging treatment and prevention using onabotulinumtoxin A: the 2010 multidisciplinary French consensus--part 1.

Background: Onabotulinumtoxin A (onabotulinum) has been used for 7 years in the treatment of the aging face. A survey was conducted to identify current practices in France.

Objective: To develop consensual practice recommendations for treating the aging upper- and mid-face with onabotulinum.

[Soft-tissue fillers].

Injections of soft-tissue fillers have rapidly become accessible and essential. When dealing with facial aging, it is logical to compensate for the loss of volume, but the optimisation of a younger face involves a 3D strategy as well.

[Subcutaneous tissue: anatomy and aging].

A deep understanding of the soft tissue from the face and its aging is necessary when dealing with facial volume injections.

[Soft-tissue fillers].

Injections of soft-tissue fillers have rapidly become accessible and essential. When dealing with facial aging, it is logical to compensate for the loss of volume, but the optimisation of a younger face involves a 3D strategy as well.

[Subcutaneous tissue: anatomy and aging].

A deep understanding of the soft tissue from the face and his aging is necessary when dealing with facial volume injections.

Pediatric emergencies in the office: are family physicians as prepared as pediatricians?

Objective: Our objective was to assess the occurrence of pediatric emergencies in the offices of family physicians and pediatricians, the preparedness to respond, and the perceived importance of being prepared.

Study Design: We performed a cross-sectional random mail survey of physicians.

Population: Surveys were sent to 187 family physicians and 129 pediatricians practicing in North Carolina with 75% and 86% response rates, respectively.

Rupture of a previously normal spleen in association with enoxaparin: An unusual cause of shock.

We report the case of an adult male presenting in shock caused by spontaneous rupture of a pathologically normal spleen. One day before his presentation he had received a single subcutaneous injection of enoxaparin. This was the patient's only clearly identifiable risk factor for spontaneous splenic rupture.

Dizziness: state of the science.

Dizziness is prevalent in all adult populations, causing considerable morbidity and utilization of health services. In the community, the prevalence of dizziness ranges from 1.8% in young adults to more than 30% in the elderly.

Impact on the care of the emergency department chest pain patient from the chest pain evaluation registry (CHEPER) study.

This study examines the question of whether chest pain observation units increase the proportion of chest pain patients with an extended evaluation for cardiac ischemia ("rule out myocardial infarction [MI] evaluation"), decrease the number of missed MIs, and decrease costs. This is a multiple site registry study of 8 established chest pain observation units (complying with the American College Emergency Physician's Observation Section's standards) compared with previous studies on chest pain evaluation without the use of observation (5 studies, 12,405 patients). A total of 23,407 of 444,189 emergency department patients (5.

Differences between chest pain observation service patients and admitted "rule-out myocardial infarction" patients.

Objective: To compare and contrast the patient characteristics of ED patients at low risk for acute cardiac ischemia who were assigned to a chest pain observation service vs those admitted to a monitored inpatient bed for "rule-out acute myocardial infarction" (R/O MI).

Methods: This was a retrospective, cross-sectional comparison of adult patients considered at relatively low risk for cardiac ischemia and who were evaluated in 1 of 2 settings: a short-term observation service and an inpatient monitored bed. All patients had an ED final diagnosis of "chest pain," "R/O MI," or "unstable angina" during the 7-month study period.

Metoclopramide in trauma CT scanning: preventing emesis of oral radiographic contrast.

Vomiting of gastric contents is common among multisystem trauma patients and may cause significant morbidity. A study was conducted to examine whether metoclopramide (Reglan), an antiemetic and promotility agent, could decrease vomiting after administration of oral radiographic contrast in stable multisystem trauma patients undergoing computed tomography (CT) of the abdomen ("trauma CT patients"). The charts of 193 patients listed in the Duke Trauma Registry who underwent abdominal CT scanning from January, 1992 until February, 1993 were reviewed.

Factors affecting ED length-of-stay in surgical critical care patients.

To determine what patient characteristics are associated with prolonged emergency department (ED) length-of-stay (LOS) for surgical critical care patients, the charts of 169 patients admitted from the ED directly to the operating room (OR) or intensive care unit (ICU) during a 6-week period in 1993 were reviewed. The ED record was reviewed for documentation of factors that might be associated with prolonged ED LOS, such as use of computed tomographic (CT), radiology special procedures, and the number of plain radiographs and consultants. ED LOS was considered to be the time from triage until a decision was made to admit the patient.

ED length-of-stay and illness severity in dizzy and chest-pain patients.

Emergency department (ED) length of stay, illness severity, and patterns of ED-based testing can be used to compare different ED patient populations. To assess the relative significance of ED patients with dizziness and chest pain in emergency medicine practice, the investigators formed a retrospective chart review of 3,864 adults (age > or = 16 years) seen at the University of North Carolina Hospitals' ED during May and June of 1991. Patients were eligible if they had any complaint of dizziness (n = 259), nontraumatic chest pain (n = 168), or both (n = 18).

Management of dizziness in primary care.

Background: We sought to determine the types of dizziness problems that are commonly seen in primary care practices, and to bring to light clinical and demographic factors that predict management decisions.

Methods: We undertook a prospective cohort study with a 6-month follow-up using data gathered in nine primary care practices in two North Carolina counties. Subjects were 144 dizziness patients examined by primary care physicians.

Collaborating with nonphysician professionals in practice-based research. Dizziness Research Group.

Although much has been written about the importance of collaboration among physicians in practice-based research, the relationship between the clinical investigator and nonphysician professionals in this setting has received less attention. Nurses, physician assistants, and other office support staff can provide valuable insights pertinent to research design and project implementation. Because nonphysician professionals frequently play a large part in implementing a research project, how well the investigator collaborates with them often determines the success or failure of the project.

Purity of standardized textile dye allergens: a thin layer chromatography study.

Twelve standard textile dyes were analyzed using thin layer chromatography and studied comparatively with dyes supposed to be chemically similar, having the same Colour Index number or Registration Code. According to the chromatograms, Disperse Yellow 3, Disperse Orange 1, Disperse Orange 3 and Disperse Orange 13 seemed, at least in the solvent system used, to be pure, while all the other dyes, in the same eluent system, seemed impure. All the standard Textile Dye allergens were similar to the dyes used in the clothing industry.