Publications by authors named "Dalin Xi"
Article Synopsis
- Bacterial lipoprotein (BLP) induces tolerance in macrophages that reduces inflammation and enhances their ability to kill bacteria, particularly during infections.
- The study found that BLP tolerance upregulates Rab20, which is important for transporting cellular components, during bacterial infections.
- Knockdown of Rab20 impairs the killing of E. coli by macrophages, as it disrupts the maturation of phagosomes and their fusion with lysosomes, highlighting Rab20's crucial role in enhancing bactericidal activity.
Mouse embryonic fibroblasts (MEFs) are commonly used in research on the molecular mechanism(s) of inflammation because of its good response to inflammatory stimuli. However, the difference in inflammatory reaction between MEFs and macrophages, a classical inflammatory cell type, has not been identified. In this study, we report that both mRNA and protein levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in MEFs upon lipopolysaccharides (LPS) stimulation were significantly lower than those in bone marrow-derived macrophages (BMDMs).
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