Spiro Heterocyclic Compounds as Potential Anti-Alzheimer Agents (Part 2): Their Metal Chelation Capacity, POM Analyses and DFT Studies.

Background: One of the best methods to treat Alzheimer disease (AD) is through the effective use of cholinesterase inhibitors as vital drugs due to the identification of acetylcholine deficit in the AD patients.

Objective: The present study aims the investigation of spiro heterocyclic compounds as potential AD agents supported by their metal chelation capacity, POM analyses and DFT studies, respectively.

Methods: The cholinesterase inhibition and metal chelation ability were performed on ELISA microtiter assay.

Synthesis and Evaluation of Curcuminoid Analogues as Antioxidant and Antibacterial Agents.

Diazocoupling reaction of curcumin with different diazonium salts of -toluidine, 2-aminopyridine, and 4-aminoantipyrine in pyridine yielded the arylhydrazones -. Arylhydrazone of -toluidine reacted with urea, thiourea, and guanidine nitrate to produce 5,6-dihydropyrimidines. Further reaction of with 2,3-diaminopyrdine in sodium ethoxide solution yielded 1-pyrido[2,3-][1,4]diazepine derivative.