The Impact of Trimethylamine N-Oxide and Coronary Microcirculatory Dysfunction on Outcomes following ST-Elevation Myocardial Infarction.

Introduction: Persistent coronary microcirculatory dysfunction (CMD) and elevated trimethylamine N-oxide (TMAO) levels after ST-elevation myocardial infarction (STEMI) may drive negative structural and electrical cardiac remodeling, resulting in new-onset atrial fibrillation (AF) and a decrease in left ventricular ejection fraction (LVEF).

Aims: TMAO and CMD are investigated as potential predictors of new-onset AF and left ventricular remodeling following STEMI.

Methods: This prospective study included STEMI patients who had primary percutaneous coronary intervention (PCI) followed by staged PCI three months later.

Angina pectoris and sinus of Valsalva aneurysm: a rare manifestation of an uncommon disease.

Sinus of Valsalva aneurysm is an uncommon finding. The present paper describes a case report of a 57-year-old female patient who developed angina pectoris due to the left sinus of Valsalva aneurysm. Clinical presentation, localization, unruptured status and concomitant coarctation of the aorta make the case presented in this document extremely rare and interesting.

[Relationship of paradoxical vasoconstriction induced by acetylcholine to risk factors for ischemic heart disease].

Acetylcholine test is widely used for the investigation of endothelium function. Acetylcholine induces paradoxical vasoconstriction, if endothelium of coronary artery is damaged. The aim of this study was to investigate the endothelium dysfunction among the patients who have complaints of the chest pain and at the same time no significant changes are found in their coronary arteries by angiography.

[Oxidative stress and endothelial dysfunction].

Growing numbers of morbidity and mortality due to the Coronary Heart Disease (CHD) is recognized as the more increasing challenge in the world. The initial stage of atherosclerosis, early diagnosis and treatment of CHD are the main objectives of current research. Endothelium dysfunction, the earliest expression of the atherosclerotic process is associated with subtle biochemical changes that gradually are transformed into the structural changes of the arterial wall.