Effect of nano-metal oxides (TiO, MgO, CaO, and ZnO) on antibacterial property of (PEO/PEC-co-AAm) hydrogel synthesized by gamma irradiation.

The global threat of infectious diseases and antibiotic resistance calls for the development of potent antimicrobial agents integrated with hydrogel for effective control and treatment. Hydrogel is advanced biomaterials compounds. Hydrogel is an advanced biomaterial compound that offers tunable physical and chemical properties, which can be tailored to specific biomedical applications.

Gamma radiation synthesis of a novel amphiphilic terpolymer hydrogel pH-responsive based chitosan for colon cancer drug delivery.

Particularly, chitosan (Cs) loaded with drug cannot pass through the colonic region, often leading in the bursting drug release in the stomach due to its solubility in gastric contents. The novelty of the current article is to solve this limitation by performing gamma irradiation cross-linking of Cs with two anionic polymers of (acrylic acid)-co-(2-acrylamido-2-methylpropane-sulfonic acid) (AAc/AMPS) to give amphiphilic hydrogel. The shifted in the characteristic FTIR peaks of Cs in the (Cs/AAc/AMPS) confirm the exits of inter-molecular interactions that make Cs and (AAc/AMPS) are miscible.