Value of immunohistochemical expression of p27 and galectin-3 in differentiation between follicular adenoma and follicular carcinoma.

Introduction: Thyroid neoplasms represent a broad spectrum of tumors with different biologic behaviors. Follicular neoplasms are classified as benign or malignant depending on the presence or absence of capsular and/or vascular invasion; however, evaluation of these features can be challenging on histopathologic examination. Galectin-3 is a member of lectin family and seems to play a significant role in a number of biological processes.