Publications by authors named "Dalia Alsaied Moustafa Ahmed"
Background: Bisphenol A (BPA) is an endocrine disrupter affecting glucose homeostasis.
Objectives: This study aimed to investigate BPA's relationship with Type 1 Diabetes Mellitus (T1DM) in Dakahlia Governorate's children, in Egypt.
Subjects Materials And Methods: The study had two parts: clinical and experimental.
Concerns regarding the possible hazards to human health have been raised by the growing usage of silica nanoparticles (SiNPs) in a variety of applications, including industrial, agricultural, and medical applications. This in vivo subchronic study was conducted to assess the following: (1) the toxicity of orally administered SiNPs on the liver, kidneys, and adrenal glands; (2) the relationship between SiNPs exposure and oxidative stress; and (3) the role of magnesium in mitigating these toxic effects. A total of 24 Sprague Dawley male adult rats were divided equally into four groups, as follows: control group, magnesium (Mg) group (50 mg/kg/d), SiNPs group (100 mg/kg/d), and SiNPs+ Mg group.
View Article and Find Full Text PDF1. The aim of this study was to compare the in vitro cytotoxic effect of tramadol and M1 metabolite in HepG2 cell line, the underlying mechanism, and PI3K/AKT/mTOR as potential target.2.
View Article and Find Full Text PDFBackground: Amiodarone (AMD) is a widely used anti-arrhythmic drug, but its administration could be associated with varying degrees of pulmonary toxicity. In attempting to circumvent this issue, AMD-loaded polymeric nanoparticles (AMD-loaded NPs) had been designed.
Materials And Methods: AMD was loaded in NPs by the nanoprecipitation method using two stabilizers: bovine serum albumin and Kolliphor P 188.
Article Synopsis
- Amiodarone (AM) is effective for treating arrhythmias, but it has side effects outside the heart that limit its use; using nanoparticles (NPs) for delivery could enhance its benefits while reducing these adverse effects.
- * The study developed AM-loaded polymeric NPs and tested them on rats, assessing liver and lung health alongside AM's effects through various biochemical and histopathological evaluations.
- * Results showed that the AM-loaded NPs reduced liver damage and other adverse effects seen in the traditional AM treatment, suggesting a promising alternative for minimizing toxicities.