The Study of SALL4 Gene and BMI-1 Gene Expression in Acute Myeloid Leukemia Patients.

Background: In acute myeloid leukemia (AML), many genes have been studied as prognostic markers. SALL4 is expressed constitutively in human leukemia cell lines and primary AML cells. BMI-1 is expressed highly in purified hematopoietic stem cells (HSCs), and its expression declines with differentiation.