Excessive Tryptophan and Phenylalanine Induced Pancreatic Injury and Glycometabolism Disorder in Grower-finisher Pigs.

Background: The increase in circulating insulin levels is associated with the onset of type 2 diabetes (T2D), and the levels of branched-chain amino acids and aromatic amino acids (AAAs) are altered in T2D, but whether AAAs play a role in insulin secretion and signaling remains unclear.

Objectives: This study aimed to investigate the effects of different AAAs on pancreatic function and on the use of insulin in finishing pigs.

Methods: A total of 18 healthy finishing pigs (Large White) with average body weight of 100 ± 1.

High-Hole-Mobility Fiber Organic Electrochemical Transistors for Next-Generation Adaptive Neuromorphic Bio-Hybrid Technologies.

The latest developments in fiber design and materials science are paving the way for fibers to evolve from parts in passive components to functional parts in active fabrics. Designing conformable, organic electrochemical transistor (OECT) structures using poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) fibers has excellent potential for low-cost wearable bioelectronics, bio-hybrid devices, and adaptive neuromorphic technologies. However, to achieve high-performance, stable devices from PEDOT:PSS fibers, approaches are required to form electrodes on fibers with small diameters and poor wettability, that leads to irregular coatings.

Targeted electrochemical reduction of carcinogenic N-nitrosamines from emission control systems within CO capture plants.

N-Nitrosamines are one of the environmentally significant byproducts from aqueous amine-based post-combustion carbon capture systems (CCS) due to their potential risk to human health. Safely mitigating nitrosamines before they are emitted from these CO capture systems is therefore a key concern before widescale deployment of CCS can be used to address worldwide decarbonization goals. Electrochemical decomposition is one viable route to neutralize these harmful compounds.

Formation of Lutein, β-Carotene and Astaxanthin in a sp. Isolate.

In this study, the effect of media composition, N/P ratio and cultivation strategy on the formation of carotenoids in a sp. isolate was investigated. A two-stage process utilizing different media in the vegetative stage, with subsequent re-suspension in medium without nitrate, was employed to enhance the formation of carotenoids.

Threonine supplementation prevents the development of fat deposition in mice fed a high-fat diet.

Obesity is the main factor involved in the onset of many diseases. Threonine supplementation has been demonstrated to reduce fat mass and serum triglycerides in already obese mice. However, it is unclear whether threonine could inhibit the development of obesity in mice without previous high-fat diet induction.

Reductive Degradation of CCl by Sulfidized Fe and Pd-Fe Nanoparticles: Kinetics, Longevity, and Morphology Aspects.

In this study a systematic comparison in morphology, long-term degradation, regeneration and reuse were conducted between palladized and sulfidized nanoscale zero-valent iron (Pd-Fe and S-Fe). Pd-Fe and S-Fe were prepared, after the synthesis of precursor Fe nanoparticles (spherical, ~35 nm radius) for carbon tetrachloride (CTC) treatment. With HAADF-TEM-EDS characterization, dispersive Pd islets were found on the Fe core of Pd-Fe.

Nanoparticle-delivered miriplatin ultrasmall dots suppress triple negative breast cancer lung metastasis by targeting circulating tumor cells.

No effective therapy is yet available to treat triple negative breast cancer (TNBC), which has poor prognosis due to frequent metastasis. Cancer stem cells (CSCs) or CSC-like cells play crucial roles in cancer metastasis and are exceptionally tolerant with genetic lesions. The extent of DNA damages has an important impact on the fate of CSCs.

Tailoring the Seebeck Coefficient of Spray-Coated Poly(3,4-ethylenedioxythiophene): Poly(styrenesulfonate) Films with Nitrogen Doped Multiwalled Carbon Nanotubes.

The thermoelectric properties of flexible thin films fabricated from two commercial poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) formulations filled with multiwalled carbon nanotubes (MWCNT) and nitrogen-doped MWCNT (N-MWCNT) were investigated. A simple spray-coating method for the fabrication of such flexible films on a polyethylene terephthalate substrate was developed. While increasing the MWCNT concentration had little effect on the thermoelectric properties, increasing the N-MWCNT concentration resulted in the emergence of an overall -type semiconducting behavior and, thereby, tailoring the Seebeck coefficient of the composite films from -type to -type was shown.

Continuous Processing of Multi-Walled Carbon Nanotube-Studded Carbon Fiber Tapes for Enhanced Through-Thickness Thermal Diffusivity Composites.

Carbon fiber reinforced polymer (CFRP) composites offer advantages over traditional metallic structures, particularly specific strength and stiffness, but at much reduced thermal conductivity. Moreover, fiber-to-fiber heat conduction in the composite transverse directions is significantly lower. When these structures contain electronics (heat generators), shortfalls in heat transport can be problematic.

Linear and spiral forms of longitudinal cuts in graphitized N-doped multiwalled carbon nanotubes (g-N-MWCNTs).

Nitrogen-containing multiwalled nanotubes (N-MWCNTs), formed by CVD from a nitrogen-containing feedstock have a 'bamboo' structure in which the axes of the graphene planes are not parallel to the axis of the nanotube and the core is periodically bridged. We find that thermal and chemical treatment of these materials can produce nanotubes that have been cut longitudinally in either a linear or in a spiral manner. In addition, these longitudinally cut nanotubes can be partially or fully unrolled by sonication in an aqueous surfactant, producing graphite platelets as well as narrow structures that could be thin graphite ribbons or very narrow, intact N-MWCNTs.

Multi-walled carbon nanotube arrays for gas sensing applications.

Vertically aligned multi-walled carbon nanotube (MWCNT) arrays fabricated by xylene pyrolysis in anodized aluminum oxide (AAO) templates without the use of a catalyst were integrated into a resistive sensor design. Steady state sensitivities as high as 5% and 10% for 100 ppm of NH(3) and NO(2), respectively, at a flow rate of 750 sccm were observed. A thin layer of amorphous carbon (5-50 nm), formed on both sides of the template during xylene pyrolysis, was part of the sensor design.

Low-temperature synthesis of large-area CNx nanotube arrays.

Well-aligned nitrogen-doped multiwall carbon nanotube arrays have been successfully grown over large areas on quartz and silicon wafers by floating-catalyst chemical vapor deposition at low temperatures (600 degrees C). These nitrogen-including nanotubes, derived from pyridine-ferrocene mixtures, have smaller outer diameters but larger inner diameters compared with carbon nanotubes grown from a xylene-ferrocene mixture under similar conditions. The N-doped nanotubes exhibit bamboo-like structures in the core.

Multiwall carbon nanotubes: synthesis and application.

Chemical vapor deposition (CVD) is the most promising synthesis route for economically producing large quantities of carbon nanotubes. We have developed a low-cost CVD process for the continuous production of aligned multiwall carbon nanotubes (MWNTs). Here we report the effects of reactor temperature, reaction time, and carbon partial pressure on the yield, purity, and size of the MWNTs produced.