Publications by authors named "Dalee Demaree"
Adv Healthc Mater
December 2024
Article Synopsis
- Microphysiological systems (MPSs) offer a promising alternative to animal models in drug development by reconstituting tissue interfaces and organ functions, although traditional materials like PDMS can interfere with drug testing accuracy.
- The GlioFlow3D platform combines 3D bioprinting and stereolithography to create hydrogel-based microchannels that better mimic human vasculature, integrating human cells and glioblastoma lines while using cost-effective materials and protocols to reduce cytotoxicity.
- This platform allows for improved drug testing accuracy, demonstrated through lower absorption of small molecules like Temozolomide, and reveals complex GBM drug resistance mechanisms influenced by the tissue microenvironment, enhancing potential for personalized therapy.
