Synopsis of recent research by authors named "Dale W Hailey"
- Dale W Hailey's recent research primarily focuses on the interplay between cellular mechanisms in neurological and metabolic diseases, with a significant emphasis on Alzheimer’s disease and pancreatic β cell dynamics during perinatal development.
- His studies highlight the role of myeloid niches in the proliferation and function of pancreatic β cells, as well as the regulatory effects of the SORL1 gene on endosomal trafficking in neurons, potentially linking genetic risk factors to pathophysiological changes in Alzheimer's disease.
- Additionally, Hailey investigates innovative microphysiological systems for modeling renal clearance of opioids in chronic kidney disease, aiming to improve therapeutic approaches and understand drug disposition in patients at risk of overdose.
