Publications by authors named "Dale Michael Ando"
Nrf2 mitigates LRRK2- and α-synuclein-induced neurodegeneration by modulating proteostasis.
Proc Natl Acad Sci U S A
January 2017
Mutations in leucine-rich repeat kinase 2 (LRRK2) and α-synuclein lead to Parkinson's disease (PD). Disruption of protein homeostasis is an emerging theme in PD pathogenesis, making mechanisms to reduce the accumulation of misfolded proteins an attractive therapeutic strategy. We determined if activating nuclear factor erythroid 2-related factor (Nrf2), a potential therapeutic target for neurodegeneration, could reduce PD-associated neuron toxicity by modulating the protein homeostasis network.
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- Glial proliferation and activation are linked to the progression of ALS and frontotemporal lobar dementia, prompting a study on the role of astrocytes in TDP-43 proteinopathies.
- Researchers created astrocytes from human stem cells with a TDP-43 mutation, discovering that they had higher TDP-43 levels, mislocalized TDP-43, and reduced survival rates.
- The study found that these mutant astrocytes did not negatively impact the survival of motor neurons, suggesting a novel pathogenic behavior specific to the mutant astrocytes and indicating that TDP-43-related diseases may not involve the non-cell-autonomous mechanisms seen in SOD1 ALS.