Synopsis of recent research by authors named "Dale Edgerton"
- Dale Edgerton's recent research primarily focuses on the mechanisms of glucose metabolism, particularly the effects of insulin delivery routes, duration of hyperinsulinemia, and the role of glucagon in hepatic glucose production in both humans and canine models.
- Key findings indicate that morning hyperinsulinemia significantly enhances afternoon hepatic glucose uptake and storage, suggesting that both the timing and duration of insulin influence glucose metabolism, which may have implications for managing conditions like insulin resistance and type 2 diabetes.
- Additionally, Edgerton's studies show that a high-fat and fructose diet induces insulin resistance and beta-cell dysfunction in dogs, highlighting the utility of this model for understanding human glucose intolerance and diabetes progression.
