Results of a Phase II Study to Determine the Efficacy and Safety of Genetically Engineered Allogeneic Human Chondrocytes Expressing TGF-β1.

Genetically engineered chondrocytes virally transduced with a transforming growth factor (TGF)-1 (TG-C [TissueGene-C]) expression vector have been shown to have potential benefits in the nonoperative management of knee osteoarthritis. Previous literature has reported on safe dosages of TG-C. Therefore, the purpose of this study was to evaluate the Phase II results and a 24-month efficacy of this injectable mixture compared with placebo in patients with Kellgren-Lawrence (K-L) grade III knee osteoarthritis.

Thrombin peptide TP508 stimulates cellular events leading to angiogenesis, revascularization, and repair of dermal and musculoskeletal tissues.

The thrombin peptide, TP508, also known as Chrysalin (OrthoLogic, Tempe, Arizona), is a twenty-three-amino-acid peptide that represents a portion of the receptor-binding domain of the native human thrombin molecule that has been identified as the binding site for a specific class of receptors on fibroblasts and other cells. Preclinical studies with this peptide have shown that it can accelerate tissue repair in both soft and hard tissues by mechanisms that appear to involve up-regulation of genes that initiate a cascade of healing events. These events include recruitment and activation of inflammatory cells, directed migration of cells (chemotaxis), cell proliferation, elaboration of extra-cellular matrix, and accelerated revascularization of the healing tissues.

Splinting the degenerative basal joint: custom-made or prefabricated neoprene?

The purpose of this study was to compare the objective, subjective, and radiographic responses of patients with carpometacarpal joint osteoarthritis (CMCJ-OA) wearing a prefabricated neoprene splint (PFN), which crosses the CMCJ and metacarpophalangeal joint, with those of patients wearing a custom-made thermoplastic short opponens splint (CMT), which crosses only the CMCJ. Patients ( N = 25) with first CMCJ stage I and II osteoarthritis were assigned randomly to wear either the PFN splint or the CMT splint for one week. After one week, the subjects rated their function in the splint and their satisfaction and pain levels on visual analogue scales.

Use of the talon hip compression screw in intertrochanteric fractures of the hip.

A retrospective analysis of a compression hip screw with four reversibly deployable talons was done. Fifty-four patients had sufficient radiographs to be included in this analysis. One-year mortality was 17% and increased to 41% by 2 years.

Biomechanical evaluation of a new type of hip compression screw with retractable talons.

Objectives: We investigated the biomechanical performance of a compression hip screw with four reversibly deployable talons. We hypothesized that the talons would increase purchase strength of the lag screw and prevent rotation of the femoral head by resisting torsional forces between the lag screw and the femoral head.

Design: Reproducible, stable two-part intertrochanteric fractures were created on matched pairs of embalmed human femurs.