Hypothalamo-pituitary-adrenal axis after a single epidural triamcinolone injection.

Purpose: To quantify adrenocorticotropin and cortisol secretion after epidural glucocorticoid injection.

Methods: Eight men (ages 25-63 year) were studied at baseline, 1, 4, and 12 weeks after triamcinolone (80 mg) injection epidurally. Adrenocorticotropin (pg/mL) and cortisol (µg/dL) were measured every 10 min for 4 h, and after Corticotropin-releasing hormone (CRH) (1 µg/kg) injection.

Neurosarcoidosis.

Neurosarcoidosis is an uncommon presentation of sarcoidosis. It is associated with significant morbidity and poor outcome. In the past decade, there has been significant progress in our understanding of the immunopathogenesis of the disease, but the etiology of this enigmatic condition still eludes us.

Neurologic manifestations of sarcoidosis.

Sarcoidosis is multisystem granulomatous disease of unknown etiology. Although the nervous system is involved in only 5% to 16% of patients, neurosarcoidosis is one of the more serious manifestations of the disease. Cranial neuropathies are common, but involvement of the mininges or the brain or spinal cord parenchyma causes more severe morbidity.