[Au]/[Ag]-catalysed synthesis of non-hydrolysable -glycosides.

Many -glycosides are found in natural products, drugs and small molecular probes. Herein, we report the synthesis of -glycosides by the [Au]/[Ag]-catalysed activation of ethynylcyclohexyl glycosyl carbonate donors. This mild, catalytic, fast and high yielding protocol enables the synthesis of a diverse array of -glycosides that were otherwise challenging to synthesize.